Light Chain Proximal Tubulopathy: Expanding the Pathologic Spectrum with and without Deposition of Crystalline Inclusions

Table 1

Clinical and morphological findings in 9 cases with light chain proximal tubulopathy.

Case no.	Age/sex	MM diagnosis before biopsy	LM: cytoplasmic granularity in	IF: cytoplasmic granular staining	EM: cytoplasmic crystals
1	54/M	MM	PT, DT, podocyte, parietal cells	Kappa linear staining in gbm and tbm	PT, podocytes, parietal, interstitial cells. Granular deposits along gbm and tbm
2	60/M	MM	PT	Lambda	None
3	38/M	MM; FS	PT	Kappa	PT, needle shape
4	51/M	MM	PT + amyloid	Lambda	None; amyloid fibrils
5	58/M	MM	PT	Kappa	PT
6	55/M	MM	PT	Lambda	None
7	59/F	MM	PT	Lambda	None
8	58/M	MM	PT + LCCN	Lambda + casts	None
9	63/M	MM	PT + LCCN	Lambda + casts	None

MM: multiple myeloma; FS: fanconi syndrome; PT: proximal tubule; DT: distal tubule, gbm: glomerular basement membrane; tbm: tubular basement membrane; LCCN: light chain cast nephropathy.