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ISRN Gastroenterology
Volume 2012 (2012), Article ID 562594, 7 pages
Review Article

Necrotizing Enterocolitis in Very Low Birth Weight Infants: A Systemic Review

Department of Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Gujarat, Mehsana 384001, India

Received 18 April 2012; Accepted 19 June 2012

Academic Editors: C.-Y. Chen and C. Sperti

Copyright © 2012 Bhoomika K. Patel and Jigna S. Shah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Necrotizing enterocolitis (NEC) is the most common serious gastrointestinal disorder affecting very preterm or very low birth weight infants. The risk is inversely proportional to gestational age and weight at birth. Fetal growth restriction and compromise may be additional specific risk factors. Despite extensive research and animal studies etiopathogenesis, preventive strategies and management options remain controversial. The present paper reviews the literature for recent advances and newer insights for changing epidemiological trends, pathogenesis, role of inflammatory cytokines, and various preventive and management strategies.