Review Article
Necrotizing Enterocolitis in Very Low Birth Weight Infants: A Systemic Review
Table 2
Clinical trials of probiotic preparations to decrease the incidence of neonatal NEC.
| Study | Site/patient population | Probiotic administration | Decrease in NEC |
| Hoyos et al. [61] | Bogota Columbia all admitted newborns historical controls singal site-1237 infants | Daily infloran until D/C (L acidophilus, B. infantis) | 2.9% versus 6.6% |
| Lin et al. [62] | Taiwan VLBW < 1500 g prospective, masked randomized control trial singal site-367 infants | 2X/day infloran until D/C (L acidophilus, B. infantis) | 1% versus 5.3% |
| Bin-Nun et al. [63] | Israel VLBW < 1500 g prospective, masked randomized control trial singal site-145 infants | Daily Abc Dophilus until 36 wks postconceptual age (B. infantis, Strep thermophilus, B. Bifidus) | 1% versus 14% |
| Lin et al. [64] | Taiwan VLBW < 1500 g prospective, masked randomized control trial multicentre-434 infants | 2X/day infloran until D/C (L acidophilus, B. infantis) | 1.8% versus 6.5% |
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