Table of Contents
ISRN Hematology
Volume 2012 (2012), Article ID 567491, 3 pages
http://dx.doi.org/10.5402/2012/567491
Research Article

Evaluation of the First Commercial Hepcidin ELISA for the Differential Diagnosis of Anemia of Chronic Disease and Iron Deficiency Anemia in Hospitalized Geriatric Patients

1Laboratory Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
2Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Received 11 November 2011; Accepted 8 December 2011

Academic Editor: C. Panizo

Copyright © 2012 Inge Geerts et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Anemia is a frequent problem in hospitalized geriatric patients, and the anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the 2 most prevalent causes. The aim of the study was to assess the possible role of serum hepcidin in the differential diagnosis between ACD and IDA. Methods. We investigated serum hepcidin, iron status, anemia, and C-reactive protein in 39 consecutive geriatric patients with ACD and IDA. Serum hepcidin levels were determined using a commercial ELISA kit (DRG Instruments, Marburg, Germany). We also measured hepcidin in 26 healthy controls. Results. The serum hepcidin levels were not significantly higher in the 28 patients with ACD as compared to the 11 patients with IDA. Conclusions. The serum hepcidin levels measured using the commercial ELISA kit (DRG) do not appear to increase in older patients with ACD. It should be noted that an assay-specific problem could explain our results.