Table of Contents
ISRN Neurology
Volume 2012, Article ID 576578, 10 pages
http://dx.doi.org/10.5402/2012/576578
Research Article

Promoter Methylation of RASSF1A Associates to Adult Secondary Glioblastomas and Pediatric Glioblastomas

1Unidad de Biología de Tumores Cerebrales, Universidad de Navarra, 31008 Pamplona, Spain
2Gene Expression and Cancer Group, Vall d’Hebrón Instituto de Oncología, 08035 Barcelona, Spain
3Departamento de Ciencias de la Salud, Universidad Pública de Navarra, 31008 Pamplona, Spain
4Servicio de Neurocirugía, Hospital de Navarra, 31008 Pamplona, Spain
5Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
6Servicio de Anatomía Patológica, Hospital Miguel Servet, 50009 Zaragoza, Spain
7Servicio de Anatomía Patológica, Hospital de Navarra, 31008 Pamplona, Spain
8Unidad de Investigación IdiPAZ, Hospital Universitario La Paz, 28046 Madrid, Spain

Received 25 August 2011; Accepted 29 September 2011

Academic Editor: C.-M. Chen

Copyright © 2012 Jorge Muñoz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Esteller, P. G. Corn, S. B. Baylin, and J. G. Herman, “A gene hypermethylation profile of human cancer,” Cancer Research, vol. 61, no. 8, pp. 3225–3229, 2001. View at Google Scholar · View at Scopus
  2. Y. Tada, M. Wada, K. I. Taguchi et al., “The association of Death-associated Protein Kinase hypermethylation with early recurrence in superficial bladder cancers,” Cancer Research, vol. 62, no. 14, pp. 4048–4053, 2002. View at Google Scholar · View at Scopus
  3. D. S. Millar, K. K. Ow, C. L. Paul, P. J. Russell, P. L. Molloy, and S. J. Clark, “Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer,” Oncogene, vol. 18, no. 6, pp. 1313–1324, 1999. View at Google Scholar · View at Scopus
  4. T. Teitz, T. Wei, M. B. Valentine et al., “Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN,” Nature Medicine, vol. 6, no. 5, pp. 529–535, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Harada, S. Toyooka, A. Maitra et al., “Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines,” Oncogene, vol. 21, no. 27, pp. 4345–4349, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Nakamura, T. Watanabe, Y. Yonekawa, P. Kleihues, and H. Ohgaki, “Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene,” Carcinogenesis, vol. 22, no. 10, pp. 1715–1719, 2001. View at Google Scholar · View at Scopus
  7. J. C. Soria, H. Y. Lee, J. I. Lee et al., “Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation,” Clinical Cancer Research, vol. 8, no. 5, pp. 1178–1184, 2002. View at Google Scholar · View at Scopus
  8. H. B. Salvesen, N. MacDonald, A. Ryan et al., “PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma,” International Journal of Cancer, vol. 91, no. 1, pp. 22–26, 2001. View at Google Scholar · View at Scopus
  9. Y. E. Whang, X. Wu, H. Suzuki et al., “Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 9, pp. 5246–5250, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Tohma, C. Gratas, W. Biernat et al., “PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas,” Journal of Neuropathology and Experimental Neurology, vol. 57, no. 7, pp. 684–689, 1998. View at Google Scholar · View at Scopus
  11. R. Albarosa, B. M. Colombo, L. Roz et al., “Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q,” American Journal of Human Genetics, vol. 58, no. 6, pp. 1260–1267, 1996. View at Google Scholar · View at Scopus
  12. P. A. Steck, H. Lin, L. A. Langford et al., “Functional and molecular analyses of 10q deletions in human gliomas,” Genes Chromosomes and Cancer, vol. 24, no. 2, pp. 135–143, 1999. View at Google Scholar · View at Scopus
  13. X. Fan, J. Muñoz, S. G. Sanko, and J. S. Castresana, “PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas,” International Journal of Oncology, vol. 21, no. 3, pp. 667–674, 2002. View at Google Scholar · View at Scopus
  14. T. Moulton, G. Samara, W. Y. Chung et al., “MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme,” American Journal of Pathology, vol. 146, no. 3, pp. 613–619, 1995. View at Google Scholar · View at Scopus
  15. R. Dammann, C. Li, J. H. Yoon, P. L. Chin, S. Bates, and G. P. Pfeifer, “Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3,” Nature Genetics, vol. 25, no. 3, pp. 315–319, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Liu, S. Tommasi, D. H. Lee, R. Dammann, and G. P. Pfeifer, “Control of microtubule stability by the RASSF1A tumor suppressor,” Oncogene, vol. 22, no. 50, pp. 8125–8136, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. M. S. Song, S. J. Song, N. G. Ayad et al., “The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex,” Nature Cell Biology, vol. 6, no. 2, pp. 129–137, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. G. Herman, J. R. Graff, S. Myöhänen, B. D. Nelkin, and S. B. Baylin, “Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9821–9826, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. L. C. Li and R. Dahiya, “MethPrimer: designing primers for methylation PCRs,” Bioinformatics, vol. 18, no. 11, pp. 1427–1431, 2002. View at Google Scholar · View at Scopus
  20. K. Taniyama, S. Goodison, R. Ito et al., “PTEN expression is maintained in sporadic colorectal tumours,” Journal of Pathology, vol. 194, no. 3, pp. 341–348, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Esteller, J. Garcia-Foncillas, E. Andion et al., “Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents,” The New England Journal of Medicine, vol. 343, no. 19, pp. 1350–1354, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Uhlmann, K. Rohde, C. Zeller et al., “Distinct methylation profiles of glioma subtypes,” International Journal of Cancer, vol. 106, no. 1, pp. 52–59, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Baeza, M. Weller, Y. Yonekawa, P. Kleihues, and H. Ohgaki, “PTEN methylation and expression in glioblastomas,” Acta Neuropathologica, vol. 106, no. 5, pp. 479–485, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Nakamura, T. Watanabe, U. Klangby et al., “p14ARF deletion and methylation in genetic pathways to glioblastomas,” Brain Pathology, vol. 11, no. 2, pp. 159–168, 2001. View at Google Scholar · View at Scopus
  25. E. E. Schmidt, K. Ichimura, K. R. Messerle, H. M. Goike, and V. P. Collins, “Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours,” British Journal of Cancer, vol. 75, no. 1, pp. 2–8, 1997. View at Google Scholar · View at Scopus
  26. L. Hesson, I. Bièche, D. Krex et al., “Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas,” Oncogene, vol. 23, no. 13, pp. 2408–2419, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Horiguchi, Y. Tomizawa, M. Tosaka et al., “Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors,” Oncogene, vol. 22, no. 49, pp. 7862–7865, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. I. H. N. Wong, J. Chan, J. Wong, and P. K. H. Tam, “Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia,” Clinical Cancer Research, vol. 10, no. 3, pp. 994–1002, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Waki, G. Tamura, M. Sato, and T. Motoyama, “Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples,” Oncogene, vol. 22, no. 26, pp. 4128–4133, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. Q. Li, A. Jedlicka, N. Ahuja et al., “Concordant methylation of the ER and N33 genes in glioblastoma multiforme,” Oncogene, vol. 16, no. 24, pp. 3197–3202, 1998. View at Google Scholar · View at Scopus
  31. D. G. Burbee, E. Forgacs, S. Zöchbauer-Müller et al., “Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression,” Journal of the National Cancer Institute, vol. 93, no. 9, pp. 691–699, 2001. View at Google Scholar · View at Scopus
  32. I. Kuzmin, J. W. Gillespie, A. Protopopov et al., “The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells,” Cancer Research, vol. 62, no. 12, pp. 3498–3502, 2002. View at Google Scholar · View at Scopus
  33. M. F. Paz, M. F. Fraga, S. Avila et al., “A systematic profile of DNA methylation in human cancer cell lines,” Cancer Research, vol. 63, no. 5, pp. 1114–1121, 2003. View at Google Scholar · View at Scopus
  34. M. Y. Arcellana-Panlilio, R. M. Egeler, E. Ujack et al., “Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors,” Genes Chromosomes and Cancer, vol. 35, no. 2, pp. 176–181, 2002. View at Publisher · View at Google Scholar · View at Scopus