Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence
Expression of interleukin-17. (a) is an IL-17 positive control (human kidney). The epithelium lining the kidney collecting ducts was strongly stained. Magnification 100. (b) is an IL-17 negative control and demonstrates IL-17 immunohistochemistry treatment within the oesophageal squamous mucosa. IL-17 staining is brown when present. Magnification 200. (c) demonstrates IL-17 expression in the columnar epithelium (without intestinal metaplasia) where IL-17 staining was absent/weak. Magnification 200. (d) demonstrates IL-17 expression in the intestinal metaplasia where the IL-17 stain intensity was moderate. Intestinal metaplastic cells surround the goblet cells. Magnification 100. (e) demonstrates IL-17 expression in the glandular neoplastic cells where IL-17 stain intensity was strong. IL-17 staining was absent within the neighbouring squamous mucosa region. Magnification 200.