Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 1

Studies included in the analysis of the effectiveness of antibiotic treatment in nonsurgical periodontal therapy.

Year and authors	Periodontal disease	Study duration	Study groups
(1) Caton et al., 2000 [10]	Chronic periodontitis	9 months	SRP + SDD
			SRP + placebo
(2) Golub et al., 2001 [7]	Chronic periodontitis	36 weeks	SRP + SDD
			SRP + placebo
(3) Novak et al., 2002 [11]	Generalized severe periodontitis	9 months	SRP + SDD
			SRP + placebo
(4) Preshaw et al., 2004 [12]	Chronic periodontitis	9 months	SRP + SDD
			SRP + placebo
(5) Preshaw et al., 2003 [13]	Chronic periodontitis	9 months	SRP + SDD
			SRP + placebo
(6) Guerrero et al., 2005 [14]	Generalized aggressive periodontitis	6 months	SRP + amoxicillin-metronidazole
			SRP + placebo
(7) Reinhardt et al., 2007 [15]	Chronic periodontitis	24 months	SRP + SDD
			SRP + placebo
(8) Needleman et al., 2007 [16]	Chronic periodontitis	6 months	SRP + SDD
			SRP + placebo
(9) Griffiths et al., 2011 [17]	Generalized aggressive periodontitis	8 months	SRP + amoxicillin-metronidazole + placebo
			SRP + placebo + amoxicillin-metronidazole

SRP: scaling and root planing; SDD: subantimicrobial dose doxycycline. 20 mg/12 hours; Amoxicillin-metronidazole: 500 mg of each/8 hours/7 days.