Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 5

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for percentage of sites with clinical attachment level gain at sites with moderate periodontitis (4–6 mm).

Percentage of sites with CAL gain at sites with moderate periodontitis (4–6 mm)						Std diff in means and 95% CI
Study	Antibiotic	Placebo	Std diff in means; 95% Cl	Z value	𝑃 value
Caton et al., 2000 [10]	90	93	0.244	1.647	0.100
Preshaw et al., 2004 [12]	10	10	0.039	0.280	0.780
Novak et al., 2002, [11]	107	102	0.775	1.672	0.940
Preshaw et al., 2008 [18]	66	76	0.530	3.096	0.002
Guerrero et al., 2005 [14]	20	21	−0.615	−1.925	0.054
Synthesis	293	302	0.197	2.382	0.017

CAL: clinical attachment level, 𝑃<0.05, confidence level 95%.