Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 9

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for percentage of sites with probing depth reduction at sites with moderate periodontitis (4–6 mm).

Percentage of sites with PD reduction at sites with moderate periodontitis (4–6 mm)						Std diff in means and 95% CI
Study	Antibiotic	Placebo	Std diff in means; 95% Cl	Z value	𝑃 value
Caton et al., 2000 [10]	90	93	0.244	1.647	0.100
Preshaw et al., 2004 [12]	10	10	0.081	0.584	0.560
Novak et al., 2002 [11]	107	102	1.296	2.634	0.008
Mohammad et al., 2005 [8]	66	76	0.530	3.096	0.002
Guerrero et al., 2005 [14]	20	21	0.797	2.426	0.015
Reinhardt et al., 2007 [15]	64	64	0.045	0.254	0.800
Griffitz et al., 2011 [17]	20	21	0.526	1.656	0.098
Synthesis	𝟑𝟕𝟕	𝟑𝟖𝟕	𝟎.𝟐𝟖𝟐	𝟑.𝟖𝟔𝟓	𝟎.𝟎𝟎𝟎

PD: probing depth, 𝑃<0.05, confidence level 95%.