Table of Contents
ISRN Obstetrics and Gynecology
Volume 2012, Article ID 581725, 7 pages
Review Article

Unveiling New Molecular Factors Useful for Detection of Pelvic Inflammatory Disease due to Chlamydia trachomatis Infection

1Dermatology Department, CHUVI and University of Vigo, 36210 Vigo, Spain
2Predoctoral Researcher in Health Sciences, University of Vigo, 36210 Vigo, Spain
3Analytical Chemistry Department, University of Vigo, 36210 Vigo, Spain
4Department of Molecular Biology, Centre for Molecular and Cellular Studies, Lugo, Spain

Received 5 August 2012; Accepted 31 August 2012

Academic Editors: J.-L. Pouly, S. San Martin, and K. Yang

Copyright © 2012 Carmen Rodriguez-Cerdeira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Untreated Chlamydia trachomatis infections in women can result in disease sequelae such as pelvic inflammatory disease (PID), ultimately culminating in tubal occlusion and infertility. While nucleic acid amplification tests can effectively diagnose uncomplicated lower genital tract infections, they are not suitable for diagnosing upper genital tract pathological sequelae. Objective. The purpose of this paper was to provide a comprehensive review of new molecular factors associated with the diagnosis and prognosis of PID. Material and Methods. The literature was searched using the key words “Chlamydia trachomatis infections,” “pelvic inflammatory disease,” and “molecular factors” in the PubMed database. Relevant articles published between 1996 and 2012 were evaluated. Conclusions. The use of new molecular factors could potentially facilitate earlier diagnosis and prognosis in women with PID due to C. trachomatis infection.