Table of Contents
ISRN AIDS
Volume 2012, Article ID 589817, 10 pages
http://dx.doi.org/10.5402/2012/589817
Review Article

Loss to Followup: A Major Challenge to Successful Implementation of Prevention of Mother-to-Child Transmission of HIV-1 Programs in Sub-Saharan Africa

1Maternal and Child Health Department, Tongji Medical College, Huazhong University of Science and Technology, Hang Kong Lu, Wuhan 430030, China
2Faculty of Health Sciences, Mzuzu University, Mzuzu, Malawi
3University of North Carolina Project, Tidziwe Centre, Private Bag A-104, Lilongwe, Malawi

Received 14 May 2012; Accepted 18 June 2012

Academic Editors: R. E. Jeeninga, S. Nisole, and M. Patel

Copyright © 2012 Fatch W. Kalembo and Maggie Zgambo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. UNAIDS, “Report on the global AIDS Epidemic,” 2010, http://www.unaids.org/globalreport/global_report.htm.
  2. WHO, “Prevention of Mother-to-child transmission of HIV-1,” 2011, http://www.who.int/HIV-1/topics/mtct/en/nm.
  3. T. M. Painter, K. L. Diaby, D. M. Matia et al., “Sociodemographic factors associated with participation by HIV-1-positive pregnant women in an intervention to prevent mother-to-child transmission of HIV in Côte d'Ivoire,” International Journal of STD and AIDS, vol. 16, no. 3, pp. 237–242, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. S. A. Jones, G. G. Sherman, and C. A. Varga, “Exploring socio-economic conditions and poor follow-up rates of HIV-exposed infants in Johannesburg, South Africa,” AIDS Care, vol. 17, no. 4, pp. 466–470, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. G. G. Sherman, S. A. Jones, A. H. Coovadia, M. F. Urban, and K. D. Bolton, “PMTCT from research to reality—results from a routine service,” South African Medical Journal, vol. 94, no. 4, pp. 289–292, 2004. View at Google Scholar · View at Scopus
  6. UNICEF, Briefing Paper, “Scaling up early infant diagnosis and linkages to care and treatment,” 2009, http://www.unicef.org/aids/files/EIDWorkingPaperJune02.pdf.
  7. K. Patel, M. A. Hernán, P. L. Williams et al., “Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting,” Clinical Infectious Diseases, vol. 46, no. 11, pp. 1751–1760, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Arrive, B. Marquis, N. Tumwesigye et al., “Response to Anti-Retroviral Therapy (ART) in children in Sub-Saharan Africa: a pooled analysis of clinical databases—the KIDS-ART-LINC collaboration,” in Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, Calif, USA, February 2007.
  9. L. A. Guay, P. Musoke, T. Fleming et al., “Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial,” The Lancet, vol. 354, no. 9181, pp. 795–802, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Badri, R. Ehrlich, R. Wood, and G. Maartens, “Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations,” AIDS, vol. 15, no. 9, pp. 1143–1148, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Perez, T. Mukotekwa, A. Miller et al., “Implementing a rural programme of prevention of mother-to-child transmission of HIV in Zimbabwe: first 18 months of experience,” Tropical Medicine and International Health, vol. 9, no. 7, pp. 774–783, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. UNAIDS, “World leaders launch plan to eliminate new HIV-1 infections among children by 2015,” 2011, http://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2011/june/20110609prglobalplanchildren/.
  13. B. Merdekios and A. Adedimeji, “Effectiveness of interventions to prevent mother-to-child transmission of HIV-1 in Southern Ethiopia,” International Journal of Women’s Health, vol. 3, pp. 359–366, 2011. View at Google Scholar
  14. T. Horvath, B. C. Madi, I. M. Iuppa, G. E. Kennedy, G. Rutherford, and J. S. Read, “Interventions for preventing late postnatal mother-to-child transmission of HIV,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD006734, 2009. View at Google Scholar · View at Scopus
  15. AVERT, “Preventing mother to child transmission PMTCT in practice,” 2011, http://www.avert.org/pmtct-hiv.htm.
  16. H. S. F. Fraser, C. Allen, C. Bailey, G. Douglas, S. Shin, and J. Blaya, “Information systems for patient follow-up and chronic management of HIV and tuberculosis: a life-saving technology in resource-poor areas,” Journal of Medical Internet Research, vol. 9, no. 4, article e29, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Reithinger, K. Megazzini, S. J. Durako, D. R. Harris, and S. H. Vermund, “Monitoring and evaluation of programmes to prevent mother to child transmission of HIV in Africa,” British Medical Journal, vol. 334, no. 7604, pp. 1143–1146, 2007. View at Google Scholar · View at Scopus
  18. S. Rosen and M. P. Fox, “Retention in HIV care between testing and treatment in Sub-Saharan Africa: a systematic review,” PLoS Medicine, vol. 8, no. 7, Article ID e1001056, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Rosen, M. P. Fox, and C. J. Gill, “Patient retention in antiretroviral therapy programs in Sub-Saharan Africa: a systematic review,” PLoS Medicine, vol. 4, no. 10, pp. 1691–1701, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Manzi, R. Zachariah, R. Teck et al., “High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting,” Tropical Medicine and International Health, vol. 10, no. 12, pp. 1242–1250, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Kasenga, A. K. Hurtig, and M. Emmelin, “Home deliveries: implications for adherence to nevirapine in a PMTCT programme in rural Malawi,” AIDS Care, vol. 19, no. 5, pp. 646–652, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. van Lettow, R. Bedell, M. Landes et al., “Uptake and outcomes of a prevention-of mother-to-child transmission (PMTCT) program in Zomba district, Malawi,” BMC Public Health, vol. 11, article 426, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Moses, C. Zimba, E. Kamanga et al., “Prevention of mother-to-child transmission: program changes and the effect on uptake of the HIVNET 012 regimen in Malawi,” AIDS, vol. 22, no. 1, pp. 83–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Chetty, L. Butler, J. Giddy, T. Crankshaw, S. Knight, and M. L. Newell, “HIV-1—transmission, mortality and loss to follow-up of HIV-1—exposed infants enrolled in a programme providing integrated PMTCT and child health services in an urban hospital in KwaZulu?Natal,” University of Kwazulu Natal, Durban, South Africa, 2011, http://www.africacentre.ac.za/Portals/0/News%20Archive/SA%20AIDS%20Conf%202011/13%20TerushaChetty.pdf.
  25. T. M. Doherty, D. McCoy, and S. Donohue, “Health system constraints to optimal coverage of the prevention of mother-to-child HIV transmission programme in South Africa: lessons from the implementation of the national pilot programme,” African Health Sciences, vol. 5, no. 3, pp. 213–218, 2005. View at Google Scholar · View at Scopus
  26. N. E. Kurewa, M. M. Munjoma, Z. M. Chirenje, S. Rusakaniko, A. Hussain, and B. Stray-Pedersen, “Compliance and loss to follow up of HIV negative and positive mothers recruited from a PMTCT programme in Zimbabwe,” The Central African Journal of Medicine, vol. 53, no. 5–8, pp. 25–30, 2007. View at Google Scholar · View at Scopus
  27. E. N. Kurewa, G. Q. Kandawasvika, F. M. Mhlanga et al., “Realities and challenges of a five year follow up of mother and child Pairs on a PMTCT program in Zimbabwe,” The Open AIDS Journal, vol. 5, pp. 51–58, 2011. View at Publisher · View at Google Scholar
  28. J. S. A. Stringer, M. Sinkala, C. C. Maclean et al., “Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia,” AIDS, vol. 19, no. 12, pp. 1309–1315, 2005. View at Google Scholar · View at Scopus
  29. P. Msellati, G. Hingst, F. Kaba, I. Vino, C. Welffens-Ekra, and F. Dabis, “Operational issues in preventing mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire, 1998-99,” Bulletin of the World Health Organization, vol. 79, no. 7, pp. 641–647, 2001. View at Google Scholar · View at Scopus
  30. T. Mute, A. Akondé, A. Doumbia et al., “The prevention of mother-to-child transmission of HIV-1 in Mali HIV-1-positive pregnant women and loss to follow-up in the Segou region,” 2011, https://docs.google.com/viewer?a=v&q=cache:d0ibePa11x0J:www.solthis.org/fr/espace-infos/documents/mali/107-110726162013201107iasromeposterpdvptmemutel/download.html+The+prevention+of+mother-to-child+transmission+of+HIV-1+in+Mali+HIV-1-positive+pregnant+women+and+loss+to+follow-up+in+the+Segou+region&hl=en&gl=hk&pid=bl&srcid=ADGEESj5aIgnUq-kZlnFI5uYvRyfb3xMgJid9m25eUsZ-2Lw26RxcBww16LiCEa-zu3Y1jRz_7M-LX6B7UGp3FJbBmVJ0puJAy5X-MJShUMAj6F9-IdSd4Mbg-PElpQLn5DnFQCvINZ2&sig=AHIEtbRLftSIAcrxQ0Wg4Bn4TGSbTYp4tQ.
  31. A. H. Mirkuzie, S. G. Hinderaker, and O. Mørkve, “Promising outcomes of a national programme for the prevention of mother-to-child HIV transmission in Addis Ababa: a retrospective study,” BMC Health Services Research, vol. 10, article 267, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. A. H. Mirkuzie, S. G. Hinderaker, M. M. Sisay, K. M. Moland, and O. Mørkve, “Current status of medication adherence and infant follow up in the prevention of mother to child HIV-1 transmission programme in Addis Ababa: a cohort study,” Journal of the International AIDS Society, vol. 14, article 50, 2011. View at Publisher · View at Google Scholar
  33. W. M. Nyandiko, B. Otieno-Nyunya, B. Musick et al., “Outcomes of HIV-exposed children in Western Kenya: efficacy of prevention of mother to child transmission in a resource-constrained setting,” Journal of Acquired Immune Deficiency Syndromes, vol. 54, no. 1, pp. 42–50, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. I. A. Moth, A. B. Ayayo, and D. O. Kaseje, “Assessment of utilisation of PMTCT services at Nyanza Provincial Hospital, Kenya,” Journal of Social Aspects of HIV/AIDS, vol. 2, no. 2, pp. 244–250, 2005. View at Google Scholar · View at Scopus
  35. H. Nuwagaba-Biribonwoha, R. T. Mayon-White, P. Okong, and L. M. Carpenter, “Challenges faced by health workers in implementing the prevention of mother-to-child HIV transmission (PMTCT) programme in Uganda,” Journal of Public Health, vol. 29, no. 3, pp. 269–274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. J. A. Raburu, “Factors influencing quality of maternal health services: a case study of Nyanza and Nakuru Provincial Hospitals,” Kenya Nursing Journal, vol. 32, no. 2, pp. 23–29, 2004. View at Google Scholar
  37. A. Coutsoudis, K. Pillay, E. Spooner, L. Kuhn, and H. M. Coovadia, “Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study,” The Lancet, vol. 354, no. 9177, pp. 471–476, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. L. D. Bwirire, M. Fitzgerald, R. Zachariah et al., “Reasons for loss to follow-up among mothers registered in a prevention-of-mother-to-child transmission program in rural Malawi,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102, no. 12, pp. 1195–1200, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. T. M. Painter, K. L. Diaby, D. M. Matia et al., “Women's reasons for not participating in follow up visits before starting short course antiretroviral prophylaxis for prevention of mother to child transmission of HIV: qualitative interview study,” British Medical Journal, vol. 329, no. 7465, pp. 543–546, 2004. View at Google Scholar · View at Scopus
  40. V. Bond, E. Chase, and P. Aggleton, “Stigma, HIV/AIDS and prevention of mother-to-child transmission in Zambia,” Evaluation and Program Planning, vol. 25, no. 4, pp. 347–356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Medley, C. Garcia-Moreno, S. McGill, and S. Maman, “Rates, barriers and outcomes of HIV serostatus disclosure among women in developing countries: implications for prevention of mother-to-child transmission programmes,” Bulletin of the World Health Organization, vol. 82, no. 4, pp. 299–307, 2004. View at Google Scholar · View at Scopus
  42. Y. Lim, J. Y. Kim, M. Rich et al., “Improving prevention of mother-to-child transmission of HIV care and related services in Eastern Rwanda,” PLoS Medicine, vol. 7, no. 7, Article ID e1000302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Mahomva, S. Greby, S. Dube et al., “HIV prevalence and trends from data in Zimbabwe, 1997–2004,” Sexually Transmitted Infections, vol. 82, no. 1, pp. i42–i47, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Baek and N. Rutenberg, “Looking backward, moving forward: implementing PMTCT programs in resource-constrained settings, Horizons studies. 1999–2007,” Horizons Synthesis Background Papers, Population Council, Washington, DC, USA, 2010. View at Google Scholar
  45. E. J. Abrams, L. Myer, A. Rosenfield, and W. M. El-Sadr, “Prevention of mother-to-child transmission services as a gateway to family-based human immunodeficiency virus care and treatment in resource-limited settings: rationale and international experiences,” American Journal of Obstetrics & Gynecology, vol. 197, no. 3, pp. S101–S106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Rouet, D. K. Ekouevi, M. L. Chaix et al., “Transfer and evaluation of an automated, low-cost real-time reverse transcription-PCR test for diagnosis and monitoring of human immunodeficiency virus type 1 infection in a West African resource-limited setting,” Journal of Clinical Microbiology, vol. 43, no. 6, pp. 2709–2717, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. B. Tonwe-Gold, D. K. Ekouevi, C. Amani-Bose et al., “Implementing family-focused HIV care and treatment: the first 2 years' experience of the mother-to-child transmission-plus program in Abidjan, Côte d'Ivoire,” Tropical Medicine and International Health, vol. 14, no. 2, pp. 204–212, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Calmy, E. Klement, R. Teck et al., “Simplifying and adapting antiretroviral treatment in resource-poor settings: a necessary step to scaling-up,” AIDS, vol. 18, no. 18, pp. 2353–2360, 2004. View at Google Scholar · View at Scopus
  49. J. S. A. Stringer, I. Zulu, J. Levy et al., “Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes,” Journal of the American Medical Association, vol. 296, no. 7, pp. 782–793, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. Bridges.org, Testing the Use of SMS Reminders in the Treatment of Tuberculosis in Cape Town, South Africa, City of Cape Town Health Directorate and the International Development Research Council (IDRC), Cape Town, South Africa, 2005.
  51. T. Tsertsvadze, T. Kakabadze, K. Shermadini et al., “Prevention of mother-to-child transmission of HIV: the Georgian experience,” Central European Journal of Public Health, vol. 16, no. 3, pp. 128–133, 2008. View at Google Scholar · View at Scopus
  52. M. Cocu, C. Thorne, R. Mǎtuşa et al., “Mother-to-child transmission of HIV infection in Romania: results from an education and prevention programme,” AIDS Care, vol. 17, no. 1, pp. 76–84, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. T. G. Heckman, A. M. Somlai, J. Peters et al., “Barriers to care among persons living with HIV/AIDS in urban and rural areas,” AIDS Care, vol. 10, no. 3, pp. 365–375, 1998. View at Google Scholar · View at Scopus
  54. P. A. Cook, J. Downing, C. P. Wheater et al., “Influence of socio-demographic factors on distances travelled to access HIV services: enhanced surveillance of HIV patients in north west England,” BMC Public Health, vol. 9, article 78, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. T. Creek, A. Tanuri, M. Smith et al., “Early diagnosis of human immunodeficiency virus in infants using polymerase chain reaction on dried blood spots in Botswana's national program for prevention of mother-to-child transmission,” Pediatric Infectious Disease Journal, vol. 27, no. 1, pp. 22–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. C. McDonald, J. Lambert, D. Nayagam et al., “Why are children still being infected with HIV? Experiences in the prevention of mother-to-child transmission of HIV in south London,” Sexually Transmitted Infections, vol. 83, no. 1, pp. 59–63, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. L. M. Mofenson, “Advances in the prevention of vertical transmission of human immunodeficiency virus,” Seminars in Pediatric Infectious Diseases, vol. 14, no. 4, pp. 295–308, 2003. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Kanshana and R. J. Simonds, “National program for preventing mother-child HIV transmission in Thailand: successful implementation and lessons learned,” AIDS, vol. 16, no. 7, pp. 953–959, 2002. View at Publisher · View at Google Scholar · View at Scopus
  59. K. Gamazina, I. Mogilevkina, Z. Parkhomenko, A. Bishop, P. S. Coffey, and T. Brazg, “Improving quality of prevention of mother-to-child HIV transmission services in Ukraine: a focus on provider communication skills and linkages to community-based non-governmental organizations,” Central European Journal of Public Health, vol. 17, no. 1, pp. 20–24, 2009. View at Google Scholar · View at Scopus
  60. J. D. Hamadani, S. N. Huda, F. Khatun, and S. M. Grantham-McGregor, “Psychosocial stimulation improves the development of undernourished children in Rural Bangladesh,” Journal of Nutrition, vol. 136, no. 10, pp. 2645–2652, 2006. View at Google Scholar · View at Scopus
  61. J. S. Mukherjee, L. Ivers, F. Leandre, P. Farmer, and H. Behforouz, “Antiretroviral therapy in resource-poor settings: decreasing barriers to access and promoting adherence,” Journal of Acquired Immune Deficiency Syndromes, vol. 43, no. 1, pp. S123–S126, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Albrecht, K. Semrau, P. Kasonde et al., “Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmission,” Journal of Acquired Immune Deficiency Syndromes, vol. 41, no. 1, pp. 114–118, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Anita, T. Delvaux, B. Elul et al., Evaluation of Access to and Utilization of Services for the Prevention of Mother-to-Child Transmission (PMTCT) of HIV-1 in Rwanda Summary Report, Ministry of Health, Kigali, Rwanda, 2007.
  64. M. Panditrao, S. Darak, V. Kulkarni, S. Kulkarni, and R. Parchure, “Socio-demographic factors associated with loss to follow-up of HIV-infected women attending a private sector PMTCT program in Maharashtra, India,” AIDS Care, vol. 23, no. 5, pp. 593–600, 2011. View at Publisher · View at Google Scholar · View at Scopus
  65. N. T. Hanh, T. M. Gammeltoft, and V. Rasch, “Number and timing of antenatal HIV testing: evidence from a community-based study in Northern Vietnam,” BMC Public Health, vol. 11, article 183, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. A. OKeeffe, J. Godwin, and R. Moodie, “HIV/AIDS in the Asia Pacific Region: analytical report for the white paper on Australia’s aid program Thailand,” 2005, http://www.hivpolicy.org/Library/HPP000676.pdf.
  67. N. Rutenberg, M. L. Field-Ngwuer, and L. Nyblade, “Community Involvement in the prevention of mother-to-child Transmission of HIV-1: insights and recommendations,” 2012, http://www.popcouncil.org/pdfs/mtct.pdf.
  68. R. Byamugisha, J. K. Tumwine, N. Semiyaga, and T. Tylleskär, “Determinants of male involvement in the prevention of mother-to-child transmission of HIV programme in Eastern Uganda: a cross-sectional survey,” Reproductive Health, vol. 7, no. 1, article 12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  69. J. Njunga and A. Blystad, “The divorce program: gendered experiences of HIV positive mothers enrolled in PMTCT programs—the case of rural Malawi,” International Breastfeeding Journal, vol. 5, article 14, 2010. View at Publisher · View at Google Scholar · View at Scopus