Implementation of Quality by Design for the Development and Validation of Pioglitazone Hydrochloride by RP-UPLC with Application to Formulated Forms

Table 8

Results of determination of PGZ in formulations and statistical comparison with the reference method.

Formulation brand name^a	Nominal amount, mg	% PGZ found^c  ± SD		t-value	F-value
		Reference method	Proposed method
Oglo-15^a	30.0	99.01 ± 0.82	98.88 ± 0.68	0.33	1.73
Neoglit-30^b	15.0	101.2 ± 0.75	99.94 ± 0.97	1.63	1.40

^aMarketed by Panacea biotec, Mumbai, India.
^bMarketed by Novus Life Sciences Private Limited, Mumbai, India.
^cMean value of five determinations. Tabulated 𝑡-value at 95% confidence level is 2.78; tabulated F-value at 95% confidence level is 6.39.