Models, Regulations, and Functions of Microtubule Severing by Katanin

Figure 3

Regulatory network of Katanin protein. Major regulations of Katanin involve cell and stage specific polyubiquitination-mediated proteasomal degradation and covalent chemical modifications (like phosphorylation) at specific aminoacid residues. Different proteins interact with Katanin and direct its activation or inactivation in specific pathway. Katanin interacting proteins cause specific localization of Katanin to specific cellular regions or mark them for modifications and/or degradation.