Table of Contents
ISRN Oncology
Volume 2012, Article ID 601810, 8 pages
http://dx.doi.org/10.5402/2012/601810
Research Article

Epithelial Cell Dissemination and Readhesion: Analysis of Factors Contributing to Metastasis Formation in Breast Cancer

1Department of Experimental Heamatology and Oncology, Clinic for Internal Medicine II, Friedrich-Schiller-University Jena, 07747 Jena, Germany
2Transfusion Center Bayreuth, D-95448 Bayreuth, Germany

Received 26 October 2011; Accepted 30 November 2011

Academic Editors: V. M. Golubovskaya and R. S. Samant

Copyright © 2012 Katya Hekimian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although considerable progress has been achieved in breast cancer diagnosis and treatment, the live-saving effect of mammography has hardly been measurable and the benefit of taxanes regarded as highly active is still a matter of debate, possibly because treatment effects have hitherto been mainly determined from the solid part of the tumor, due to lack of measurability of the systemic part of the disease. Here, we have quantified the influence on the systemic disease, cells mobilized from the solid tumor. Increased numbers of circulating epithelial cells were observed in screened individuals and still higher numbers in breast cancer patients with repeated mammograms as compared to mammogram naïve individuals. Taxanes as part of the subsequent systemic treatment led to mobilization of tumor suspect cells in up to 78% cases and the majority of relapses have occurred in these patients. Surgery-induced activation of disseminated cells may additionally contribute to metastasis formation.