Table of Contents
ISRN Obstetrics and Gynecology
Volume 2012, Article ID 607906, 5 pages
Research Article

Outcome of Vaginal Progesterone as a Tocolytic Agent: Randomized Clinical Trial

1Feto-Maternal Unit, Mahdiyeh Hospital, No. 16, Fadaieaneslam Street, Shoush Avenue, Tehran 1185817311, Iran
2Department of Obstetrics and Gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1185817307, Iran

Received 9 December 2011; Accepted 15 February 2012

Academic Editor: P. G. Larsson

Copyright © 2012 Soraya Saleh Gargari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vaginal progesterone has a potential beneficial effect in postponing of preterm labor by suppression of prostaglandins cascades. Although different studies evaluated the use of progesterone for preterm birth, the exact effect of which on prolongation of pregnancy remains unclear. Seventy two women who underwent preterm labor were managed by magnesium sulfate. Then they were randomly assigned to continue pregnancy either by applying vaginal progesterone (400 mg) until delivery or without using any drug. Gestational age mean at the time of delivery ( 𝑃 = 0 . 0 3 9 ) and postponing delivery mean time ( 𝑃 = 0 . 0 4 8 ) were significantly higher in progesterone group. Comparison of neonatal outcomes between two groups of patients showed meaningful benefits of progesterone in increasing of neonatal weight, reduction of low birth weight babies, and lowing neonate admitted in NICU.