Table of Contents
ISRN Dentistry
Volume 2012 (2012), Article ID 617245, 5 pages
http://dx.doi.org/10.5402/2012/617245
Clinical Study

Lymphotoxin-Alpha Gene Polymorphism +252A/G (rs909253, A/G) Is Associated with Susceptibility to Chronic Periodontitis: A Pilot Study

1Division of Histology and Embryology, School of Biomedicine, Federal University of Piauí, 64049-550 Parnaíba, PI, Brazil
2Division of Histology and Embryology, Federal University of Campina Grande, 58109-990 Patos, PB, Brazil
3Department of Morphology, Division of Histology, School of Dentistry at Piracicaba, University of Campinas, 13083-970 Piracicaba, SP, Brazil
4Department of Morphology, Division of Histology, Institute São Leopoldo Mandic, 13045-610 Campinas, SP, Brazil
5Division of Histology and Embryology, School of Physiotherapy, Federal University of Piauí, 64049-550 Parnaíba, PI, Brazil
6Center for Oral and Systemic Diseases, Department of Periodontology, UNC School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7450, USA

Received 26 July 2012; Accepted 26 August 2012

Academic Editors: C. Lekic and A. Vissink

Copyright © 2012 Daniel Fernando Pereira Vasconcelos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. S. Kornman and H. Löe, “The role of local factors in the etiology of periodontal diseases,” Periodontology 2000, vol. 2, pp. 83–97, 1993. View at Google Scholar · View at Scopus
  2. R. A. Reinhardt, M. P. Masada, W. B. Kaldahl et al., “Gingival fluid IL-1 and IL-6 levels in refractory periodontitis,” Journal of Clinical Periodontology, vol. 20, no. 3, pp. 225–231, 1993. View at Google Scholar · View at Scopus
  3. Y. Shimada, H. Tai, M. Endo et al., “Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis,” Journal of Clinical Periodontology, vol. 31, no. 6, pp. 463–469, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. R. M. Scarel-Caminaga, P. C. Trevilatto, A. P. Souza, R. B. Brito, and S. R. P. Line, “Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population,” Journal of Clinical Periodontology, vol. 30, no. 4, pp. 341–345, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Shibani, R. Shhab, and R. Khattab, “Analysis of IL-1α(-889) and IL-1B(+3953) gene polymorphism in Syrian patients with aggressive periodontitis: a pilot study,” ISRN Dentistry, vol. 2011, Article ID 682564, 5 pages, 2011. View at Publisher · View at Google Scholar
  6. R. C. Page, S. Offenbacher, H. E. Schroeder, G. J. Seymour, and K. S. Kornman, “Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions,” Periodontology 2000, vol. 1997, no. 14, pp. 216–248, 1997. View at Google Scholar · View at Scopus
  7. G. C. Armitage, “Development of a classification system for periodontal diseases and conditions.,” Annals of periodontology / the American Academy of Periodontology, vol. 4, no. 1, pp. 1–6, 1999. View at Google Scholar · View at Scopus
  8. G. Messer, U. Spengler, M. C. Jung et al., “Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-β gene correlates with a variant amino acid in position 26 and a reduced level of TNF-β production,” Journal of Experimental Medicine, vol. 173, no. 1, pp. 209–219, 1991. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Boraska, N. W. Rayner, C. J. Groves et al., “Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes,” BMC Medical Genetics, vol. 11, no. 1, p. 69, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Newton, S. M. J. Harney, A. E. Timms et al., “Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis,” Arthritis and Rheumatism, vol. 50, no. 7, pp. 2122–2129, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. V. Albuquerque, C. M. Hayden, L. J. Palmer et al., “Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma,” Clinical and Experimental Allergy, vol. 28, no. 5, pp. 578–584, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Ozaki, Y. Ohnishi, A. Iida et al., “Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction,” Nature Genetics, vol. 32, no. 4, pp. 650–654, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Ramasawmy, K. C. Fae, E. Cunha-Neto et al., “Polymorphisms in the gene for lymphotoxin-α predispose to chronic chagas cardiomyopathy,” Journal of Infectious Diseases, vol. 196, no. 12, pp. 1836–1843, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Fassmann, L. I. Holla, D. Buckova, A. Vasku, V. Znojil, and J. Vanek, “Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population,” Journal of Periodontal Research, vol. 38, no. 4, pp. 394–399, 2003. View at Google Scholar · View at Scopus
  15. R. Ramasawmy, K. C. Fae, E. Cunha-Neto et al., “Polymorphisms in the gene for lymphotoxin-α predispose to chronic chagas cardiomyopathy,” Journal of Infectious Diseases, vol. 196, no. 12, pp. 1836–1843, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. E. McColl, H. Watabe, and M. H. Derakhshan, “Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors,” American Journal of Gastroenterology, vol. 102, no. 9, pp. 1893–1895, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. P. C. Trevilatto and S. R. P. Line, “Use of buccal epithelial cells for PCR amplification of large DNA fragments,” Journal of Forensic Odonto-Stomatology, vol. 18, no. 1, pp. 6–9, 2000. View at Google Scholar · View at Scopus
  18. F. Stüber, M. Petersen, F. Bokelmann, and U. Schade, “A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis,” Critical Care Medicine, vol. 24, no. 3, pp. 381–384, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. G. P. Garlet, “Critical reviews in oral biology & medicine: destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints,” Journal of Dental Research, vol. 89, no. 12, pp. 1349–1363, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. K. S. Kornman, R. C. Page, and M. S. Tonetti, “The host response to the microbial challenge in periodontitis: assembling the players,” Periodontology 2000, vol. 1997, no. 14, pp. 33–53, 1997. View at Google Scholar · View at Scopus
  21. T. C. Hart and K. S. Kornman, “Genetic factors in the pathogenesis of periodontitis,” Periodontology 2000, vol. 1997, no. 14, pp. 202–215, 1997. View at Google Scholar · View at Scopus
  22. P. C. Trevilatto, A. P. De Souza Pardo, R. M. Scarel-Caminaga et al., “Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians,” Archives of Oral Biology, vol. 56, no. 1, pp. 54–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Zhang, A. Crivello, S. Offenbacher, A. Moretti, D. W. Paquette, and S. P. Barros, “Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis,” Journal of Clinical Periodontology, vol. 37, no. 11, pp. 953–961, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. R. M. Scarel-Caminaga, P. C. Trevilatto, A. P. Souza, R. B. Brito, and S. R. P. Line, “Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population,” Journal of Clinical Periodontology, vol. 30, no. 4, pp. 341–345, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. P. de Souza, P. C. Trevilatto, R. M. Scarel-Caminaga, R. B. de Brito, S. P. Barros, and S. R. P. Line, “Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis,” Journal of Clinical Periodontology, vol. 32, no. 2, pp. 207–211, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. R. B. de Brito Jr, R. M. Scarel-Caminaga, P. C. Trevilatto, A. P. de Souza, and S. Pereira Barros, “Polymorphisms in the vitamin D receptor gene are associated with periodontal disease,” Journal of Periodontology, vol. 75, no. 8, pp. 1090–1095, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. M. J. Santos, D. Carmona-Fernandes, J. Caetano-Lopes et al., “TNF promoter -308 G>A and LTA 252 A>G polymorphisms in Portuguese patients with systemic lupus erythematosus,” Rheumatology International, vol. 32, no. 8, pp. 2239–2244, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Karakus, N. Kara, A. N. Ulusoy, C. Özaslan, and Y. Bek, “Tumor necrosis factor alpha and beta and interferon gamma gene polymorphisms in turkish breast cancer patients,” DNA and Cell Biology, vol. 30, no. 6, pp. 371–377, 2011. View at Publisher · View at Google Scholar · View at Scopus