Table of Contents
ISRN Oncology
Volume 2012 (2012), Article ID 638352, 6 pages
http://dx.doi.org/10.5402/2012/638352
Clinical Study

Time-Dependent Changes of Plasma Concentrations of Angiopoietins, Vascular Endothelial Growth Factor, and Soluble Forms of Their Receptors in Nonsmall Cell Lung Cancer Patients Following Surgical Resection

1Department of Pathobiochemistry and Clinical Chemistry, College of Medicine, Nicolaus Copernicus University, M. Skłodowska-Curie 9 Street, 85-094 Bydgoszcz, Poland
2Department of Thoracic Surgery and Tumors, Oncology Centre, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland
3Department of Oncology and Brachytherapy, College of Medicine, Nicolaus Copernicus University and Oncology Centre, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland
4Department of Laboratory Diagnostics, Oncology Centre in Bydgoszcz, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland

Received 2 January 2012; Accepted 22 January 2012

Academic Editors: J. Klijanienko and S. Ran

Copyright © 2012 Ewa Kopczyńska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. T. M. Van Rens, A. Brutel de la Rivière, H. R. J. Elbers, and J. M. M. Van den Bosch, “Prognostic assessment of 2,361 patients who underwent pulmonary resection for non-small cell lung cancer, stage I, II, and IIIA,” Chest, vol. 117, no. 2, pp. 374–379, 2000. View at Google Scholar · View at Scopus
  2. D. Fang, D. Zhang, G. Huang, R. Zhang, L. Wang, and D. Zhang, “Results of surgical resection of patients with primary lung cancer: a retrospective analysis of 1,905 cases,” Annals of Thoracic Surgery, vol. 72, no. 4, pp. 1155–1159, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Gao, D. J. Nolan, A. S. Mellick, K. Bambino, K. McDonnell, and V. Mittal, “Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis,” Science, vol. 319, no. 5860, pp. 195–198, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Gao, D. Nolan, K. McDonnell et al., “Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression,” Biochimica et Biophysica Acta, vol. 1796, no. 1, pp. 33–40, 2009. View at Publisher · View at Google Scholar
  5. K. Nowak, N. Rafat, S. Belle et al., “Circulating endothelial progenitor cells are increased in human lung cancer and correlate with stage of disease,” European Journal of Cardio-Thoracic Surgery, vol. 37, no. 4, pp. 758–763, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Dome, J. Timar, J. Dobos et al., “Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer,” Cancer Research, vol. 66, no. 14, pp. 7341–7347, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Hilbe, S. Dirnhofer, F. Oberwasserlechner et al., “CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer,” Journal of Clinical Pathology, vol. 57, no. 9, pp. 965–969, 2004. View at Publisher · View at Google Scholar
  8. C. H. Yoon, J. Hur, K. W. Park et al., “Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: The role of angiogenic cytokines and matrix metalloproteinases,” Circulation, vol. 112, no. 11, pp. 1618–1627, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Ferrara, “Role of vascular endothelial growth factor in regulation of physiological angiogenesis,” American Journal of Physiology, vol. 280, no. 6, pp. C1358–C1366, 2001. View at Google Scholar · View at Scopus
  10. H. Takahashi and M. Shibuya, “The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions,” Clinical Science, vol. 109, no. 3, pp. 227–241, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. C. J. Robinson and S. E. Stringer, “The splice variants of vascular endothelial growth factor (VEGF) and their receptors,” Journal of Cell Science, vol. 114, no. 5, pp. 853–865, 2001. View at Google Scholar · View at Scopus
  12. F. T. H. Wu, M. O. Stefanini, F. M. Gabhann, C. D. Kontos, B. H. Annex, and A. S. Popel, “A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use,” Journal of Cellular and Molecular Medicine, vol. 14, no. 3, pp. 528–552, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Eklund and B. R. Olsen, “Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling,” Experimental Cell Research, vol. 312, no. 5, pp. 630–641, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. N. P. J. Brindle, P. Saharinen, and K. Alitalo, “Signaling and functions of angiopoietin-1 in vascular protection,” Circulation Research, vol. 98, no. 8, pp. 1014–1023, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Fukuhara, K. Sako, K. Noda, J. Zhang, M. Minami, and N. Mochizuki, “Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis,” Histology and Histopathology, vol. 25, no. 3, pp. 387–396, 2010. View at Google Scholar · View at Scopus
  16. P. Reusch, B. Barleon, K. Weindel et al., “Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood,” Angiogenesis, vol. 4, no. 2, pp. 123–131, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Hu, B. Li, G. Shi, C. Rong, and G. Gao, “Correlation of postoperative serum VEGF levels with platelet counts in non-small cell lung cancer,” Chinese Journal of Lung Cancer, vol. 13, no. 2, pp. 118–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Hu, B. Li, and C. Song, “Clinical research of perioperative serum VEGF and MMP-9 levels in patients with non-small cell lung cancer,” Chinese Journal of Lung Cancer, vol. 11, no. 5, pp. 734–738, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Kong, C. W. Michalski, H. Friess, and J. Kleeff, “Surgical procedure as an inducer of tumor angiogenesis,” Experimental Oncology, vol. 32, no. 3, pp. 186–189, 2010. View at Google Scholar · View at Scopus
  20. J. Pouysségur, F. Dayan, and N. M. Mazure, “Hypoxia signalling in cancer and approaches to enforce tumour regression,” Nature, vol. 441, no. 7092, pp. 437–443, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Arany, S. Y. Foo, Y. Ma et al., “HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α,” Nature, vol. 451, no. 7181, pp. 1008–1012, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Carmeliet, “Angiogenesis in life, disease and medicine,” Nature, vol. 438, no. 7070, pp. 932–936, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Belizon, E. Balik, P. Horst et al., “Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection,” Surgical Endoscopy and Other Interventional Techniques, vol. 22, no. 2, pp. 287–297, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. H. M. C. Shantha Kumara, J. C. Cabot, A. Hoffman et al., “Minimally invasive colon resection is associated with a transient increase in plasma sVEGFR1 levels and a decrease in sVEGFR2 levels during the early postoperative period,” Surgical Endoscopy and Other Interventional Techniques, vol. 23, no. 4, pp. 694–699, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. H. M. C. Shantha Kumara, M. J. Grieco, X. Yan et al., “Minimally invasive colorectal resection for cancer is associated with a short-lived decrease in soluble Tie-2 receptor levels, which may transiently inhibit VEGF-mediated angiogenesis (via altered blood levels of free Ang-1 and Ang-2),” Surgical Endoscopy and Other Interventional Techniques, vol. 24, no. 10, pp. 2581–2587, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. H. M. C. Shantha Kumara, D. Feingold, M. Kalady et al., “Colorectal resection is associated with persistent proangiogenic plasma protein changes: Postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion,” Annals of Surgery, vol. 249, no. 6, pp. 973–977, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. H. F. Dvorak, “Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy,” Journal of Clinical Oncology, vol. 20, no. 21, pp. 4368–4380, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Ito, H. Hasuda, H. Terai, and T. Kitajima, “Culture of human umbilical vein endothelial cells on immobilized vascular endothelial growth factor,” Journal of Biomedical Materials Research Part A, vol. 74, no. 4, pp. 659–665, 2005. View at Publisher · View at Google Scholar
  29. J. Trapé, J. Buxó, and J. P. De Olaguer, “Serum concentrations of vascular endothelial growth factor in advanced non-small cell lung cancer,” Clinical Chemistry, vol. 49, no. 3, pp. 523–525, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Shimanuki, K. Takahashi, R. Cui et al., “Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer,” Lung, vol. 183, no. 1, pp. 29–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Asahara, D. Chen, T. Takahashi et al., “Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF- induced postnatal neovascularization,” Circulation Research, vol. 83, no. 3, pp. 233–240, 1998. View at Google Scholar · View at Scopus
  32. J. Holash, P. C. Maisonpierre, D. Compton et al., “Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF,” Science, vol. 284, no. 5422, pp. 1994–1998, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. H. P. Joo, J. P. Kwang, S. K. Young et al., “Serum angiopoietin-2 as a clinical marker for lung cancer,” Chest, vol. 132, no. 1, pp. 200–206, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. G. J. Caine, A. D. Blann, P. S. Stonelake, P. Ryan, and G. Y. H. Lip, “Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: A comparison with VEGF and Flt-1,” European Journal of Clinical Investigation, vol. 33, no. 10, pp. 883–890, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Kopczyńska, R. Makarewicz, M. Biedka, A. Kaczmarczyk, H. Kardymowicz, and T. Tyrakowski, “Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer,” European Journal of Gynaecological Oncology, vol. 30, no. 6, pp. 646–649, 2009. View at Google Scholar · View at Scopus
  36. A. Eggert, N. Ikegaki, J. Kwiatkowski, H. Zhao, G. M. Brodeur, and B. P. Himelstein, “High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas,” Clinical Cancer Research, vol. 6, no. 5, pp. 1900–1908, 2000. View at Google Scholar · View at Scopus
  37. Y. Reiss, M. R. Machein, and K. H. Plate, “The role of angiopoietins during angiogenesis in gliomas,” Brain Pathology, vol. 15, no. 4, pp. 311–317, 2005. View at Google Scholar · View at Scopus
  38. T. Nakayama, G. Hatachi, C. Y. Wen et al., “Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors,” World Journal of Gastroenterology, vol. 11, no. 7, pp. 964–969, 2005. View at Google Scholar · View at Scopus
  39. W. S. Moon, K. H. Rhyu, M. J. Kang et al., “Overexpression of VEGF and angiopoietin 2: A key to high vascularity of hepatocellular carcinoma?” Modern Pathology, vol. 16, no. 6, pp. 552–557, 2003. View at Publisher · View at Google Scholar · View at Scopus