Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 653465, 7 pages
http://dx.doi.org/10.5402/2012/653465
Research Article

Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans

1Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Maharashtra, Shirpur 425405, India
2Formulation and Development Department, Shreya Life Sciences Pvt. Ltd., MIDC, Waluj, Maharashtra, Aurangabad 431001, India

Received 23 October 2012; Accepted 11 November 2012

Academic Editors: K. Goracinova and M. R. Jaafari

Copyright © 2012 Vijay D. Wagh and Onkar J. Deshmukh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesicle size, entrapment efficiency, and drug release were markedly dependent on surfactant : cholesterol ratio and quantity of ethanol used. Permeation of the drug through the skin was affected by cholesterol content in formulation. Itraconazole niosome were having larger zone of inhibition than marketed formulation when activity was checked against C. albicans. Niosomes may be a promising carrier for topical delivery of Itraconazole especially due to their simple production.