Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Figure 4

Nociceptive behavior of rats in the early phase (0–5 min) and late phase (15–30 min) after injection of formalin recorded as amount of time (s) spent licking the injected paw following treatment with ibuprofen, ZM4, and ZM5 (all at 20 mg/kg dose). Values are expressed as mean ± S.E.M. (𝑛=8). Symbols represent statistical significance against control group as ^∗𝑃<0.05 and ^∗∗𝑃<0.001.