Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Table 1

Rats hematological parameters following a 10-day administration of ZM4 and ZM5.

Parameter	Control		ZM4 50 mg/kg		ZM5 50 mg/kg
	Males	Females	Males	Females	Males	Females
RBC (×10^6/μL)	5.5 ± 0.2	5.4 ± 0.3	6.2 ± 0.1*	8.4 ± 0.8*	9.0 ± 0.1*	8.3 ± 0.5*
HB (g/dL)	14.3 ± 0.4	14.2 ± 0.6	15.2 ± 0.3	21.2 ± 1.6**	21.5 ± 0.2**	20.1 ± 1.1**
PCV (%)	29.6 ± 0.2	29.4 ± 1.0	31 ± 0.6*	42.9 ± 3.3*	43.6 ± 0.5*	40.5 ± 2.3*
WBC (×10^3/μL)	10.5 ± 1.3	6.3 ± 0.2	9.2 ± 1.0	7.9 ± 1.2	8.1 ± 1.5	6.0 ± 0.8
Neutrophil (%)	9.8 ± 1.9	11.7 ± 1.2	12.9 ± 1.3	15.1 ± 1.7	15.9 ± 1.7	16.3 ± 3.4
Lymphocyte (%)	78 ± 3.2	74.2 ± 1.8	72.3 ± 2.7	70.1 ± 3.2	69.7 ± 1.9	70.4 ± 3.1
Monocyte (%)	12.2 ± 1.9	14.1 ± 1.2	14.8 ± 1.5	14.9 ± 1.6	14.4 ± 0.5	13.3 ± 1.1
Platelets (×10^3/μL)	663 ± 138	780 ± 96	904 ± 182	679 ± 105	399 ± 52	395 ± 46

* P < 0.01; **P < 0.001.