Research Article
Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives
Table 2
Rats serum biochemical levels following a 10-day administration of ZM4 and ZM5.
| Parameters
| Control | ZM4 50 mg/kg | ZM5 50 mg/kg |
| Cholesterol (mg/dL)
| 72 ± 9 | 86 ± 3 | 85 ± 5 | Triglyceride (mg/dL)
| 61 ± 6 | 66 ± 7 | 92 ± 8* | Total protein (g/L)
| 67 ± 5 | 75 ± 2 | 77 ± 2 | Albumin (g/L)
| 41 ± 1 | 42 ± 1 | 42 ± 1 | GGT (IU/L)
| 0.6 ± 0.2 | 0.6 ± 0.1 | 0.9 ± 0.2 | GPT (IU/L)
| 79 ± 8 | 73 ± 3 | 67 ± 5 | GOT (IU/L)
| 125 ± 10 | 125 ± 6 | 126 ± 4 | ALP (IU/L)
| 561 ± 68 | 527 ± 57 | 545 ± 78 | Glucose (mg/dL)
| 170 ± 7 | 177 ± 7 | 177 ± 5 | Urea (mg/dL)
| 46 ± 3 | 43 ± 2 | 40 ± 2 | Creatinine (mg/dL)
| 0.2 ± 0.0 | 0.2 ± 0.0 | 0.4 ± 0.1* |
|
|
*
P < 0.05.
|