Research Article

Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Table 2

Rats serum biochemical levels following a 10-day administration of ZM4 and ZM5.

Parameters
ControlZM4 50 mg/kgZM5 50 mg/kg

Cholesterol (mg/dL)
72 ± 9 86 ± 385 ± 5
Triglyceride (mg/dL)
61 ± 666 ± 792 ± 8*
Total protein (g/L)
67 ± 575 ± 277 ± 2
Albumin (g/L)
41 ± 142 ± 142 ± 1
GGT (IU/L)
0.6 ± 0.20.6 ± 0.10.9 ± 0.2
GPT (IU/L)
79 ± 873 ± 367 ± 5
GOT (IU/L)
125 ± 10125 ± 6126 ± 4
ALP (IU/L)
561 ± 68527 ± 57545 ± 78
Glucose (mg/dL)
170 ± 7177 ± 7177 ± 5
Urea (mg/dL)
46 ± 343 ± 240 ± 2
Creatinine (mg/dL)
0.2 ± 0.00.2 ± 0.00.4 ± 0.1*

* P < 0.05.