Table of Contents
ISRN Hematology
Volume 2012, Article ID 659191, 6 pages
http://dx.doi.org/10.5402/2012/659191
Research Article

Pattern of 𝜷 -Thalassemia and Other Haemoglobinopathies: A Cross-Sectional Study in Bangladesh

Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh

Received 7 March 2012; Accepted 24 April 2012

Academic Editors: G. Lucarelli, K. Tani, and B. Wachowicz

Copyright © 2012 M. Mesbah Uddin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thalassemia and other structural haemoglobinopathies are the major erythrocyte formation disorder prevalent in certain parts of the world including Bangladesh. We investigated 600 cases of anaemic patients referred from various parts of the country for diagnosis and counselling during 3 months (April to June 2011) of time. The most common form of haemoglobin (Hb) formation disorder observed in 600 subjects studied was β-thalassemia minor (21.3%). Two other conditions, such as E-β-Thalassemia and HbE trait, were also fairly common (13.5 and 12.1%, resp.) in the total subjects studied. Other forms of haemoglobin formation disorders observed were HbE disease (9.2%), Hb D/S trait (0.7%), β-thalassemia major (0.5%), and δ-β-thalassemia (0.5%). The majority of the haemoglobinopathies belonged to neonatal to childhood period (0–15 years), followed by reproductive age group (16–45 years). Few old-age (46 + years) cases were also detected in course of clinical complications.