Comparison of Whole Genome Amplification Methods for Analysis of DNA Extracted from Microdissected Early Breast Lesions in Formalin-Fixed Paraffin-Embedded Tissue

<table>Example of aCGH analysis of FFPE breast cancer samples. Chromosomes 17 (upper panel) and 7 (lower panel) analyzed by moving average (upper graphs of both Ch17 and Ch7 panels) and segmentation (lower graphs). Ch17 of this sample showed amplifications at 17q12-21 centered at the HER2/neu gene, a broad region of gain on distal 17q, three regions of gain and one region of loss on 7q. SCOMP amplified samples resolved all segments and peaks identified in nonamplified control DNA, while DOP amplified samples had significant alterations of the profiles.</table>

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Figure 3: Comparison of Whole Genome Amplification Methods for Analysis of DNA Extracted from Microdissected Early Breast Lesions in Formalin-Fixed Paraffin-Embedded Tissue 

Figure 3 | Comparison of Whole Genome Amplification Methods for Analysis of DNA Extracted from Microdissected Early Breast Lesions in Formalin-Fixed Paraffin-Embedded Tissue 