Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

<table> Effect of amounts of calcium alginate and HPMC K4M on hardness (kg/cm<sup>2</sup>)  presented by response surface plot (a), and contour plot (b).</table>

International Scholarly Research Notices

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Figure 6

Figure 6: Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release 