International Scholarly Research Notices / 2012 / Article / Tab 2

Research Article

Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Table 2

23 factorial designs and their observed response values with drug contents in bisoprolol fumarate matrix tablets.

Formulation codesCalcium alginate (mg) 
HPMC K4M (mg) 
Carbopol 943 (mg) 
Responses
6h (%)a,bHardness (kg/cm2)b

F-115 (−1)0 (−1)0 (−1)74.62 ± 2.363.19 ± 0.25
F-230 (+1)20 (+1)20 (+1)46.15 ± 2.124.18 ± 0.15
F-330 (+1)0 (−1)0 (−1)65.07 ± 3.543.52 ± 0.20
F-430 (+1)20 (+1)0 (−1)51.32 ± 3.253.84 ± 0.15
F-515 (−1)20 (+1)20 (+1)50.39 ± 2.164.10 ± 0.10
F-615 (−1)0 (−1)20 (+1)62.33 ± 1.923.90 ± 0.30
F-730 (+1)0 (−1)20 (+1)55.85 ± 2.223.93 ± 0.10
F-815 (−1)20 (+1)0 (−1)59.17 ± 1.823.41 ± 0.25

a 6h (%): cumulative drug release after 6 hours; bmean ± S.D., = 6; , , and represent the main effects (factors); (+1): higher value and (−1): lower value.

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