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Potential hazard | Outcome investigated | Evidence base | Association between exposure and outcome* |
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Pesticides | Childhood cancer | Systematic review1 [11] | + |
Pesticides | Reproductive effects: birth defects, fetal death, altered growth, and other outcomes. | Systematic review [12] | + |
Residual pesticides, insecticides and herbicides | Childhood leukaemia | Systematic review [13] | + |
Pesticides (parental exposure to) | Childhood leukaemia | Systematic review [14] | + |
Air pollution | Fetal growth | Systematic review [15] | + |
Air pollution | Fetal growth Respiratory deaths | Systematic review [16] | ± |
Air pollution | Fetal growth Duration of pregnancy | Systematic review [17] | ± |
Air pollution | Fetal growth and duration of pregnancy | Systematic review [18] | ± |
Polychlorinated biphenyls (PCBs) | Child neurodevelopment | Systematic review [19] | + |
Electromagnetic fields (nonionizing radiation) | Childhood leukaemia | Systematic review [20] | ± |
Low level radio-frequency | Birth defects, fertility, neuroblastoma in offspring, & reproductive hormones | Literature review [21] | ± |
Parental smoking | Childhood cancer | Systematic review [22] | + |
Working in floriculture (exposed to, physical activity, temperatures & pesticides) | Spontaneous abortion and birth defects | Meta-analysis of two studies [23] | + |
Nitrates in drinking water | Spontaneous abortions, intrauterine growth restriction, and various birth defects | Literature review [24] | ± |
Agent Orange (dioxin) | Birth defects | Systematic review [25] | + |
Working in hairdressers—exposure to hair products | Fertility and pregnancy complications Birth malformations particularly orofacial cleft | Systematic review [26] | ± |
Diagnostic X-rays | Childhood cancer | Systematic review [27] | ± |
Tritium | Various | Systematic review [28] | ± |
Environmental oestrogens | Male reproductive health | Systematic review [29] | ± |
Lead, polychlorinated biphenyls, mercury, cocaine, alcohol, marijuana, cigarettes and antidepressants. | Mental health in children and adolescents | Systematic review [30] | + for some exposure ± for others |
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