International Scholarly Research Notices / 2012 / Article / Tab 3

Research Article

Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis

Table 3

Stability results for rizatriptan under different conditions.

StabilityStorage conditionLevelMean stability samplea
(ng/mL)
% CV% change

Bench top stabilityRoom temperature (24 h)LQC0.571.6−5.0
HQC45.191.90.4
Processed sample stability
(extracted samples)
Auto sampler (4°C, 72 h)LQC0.591.9−1.7
HQC41.701.8−7.3
Processed sample stability
(extracted samples)
Room temperature (72 h)LQC0.582.9−3.3
HQC42.132.3−6.4
Freeze and thaw stabilityAfter 6th cycle at −20°CLQC0.563.8−6.7
HQC45.392.70.9
Long-term stability79 days at −20°CLQC0.602.20.0
HQC45.501.51.1

% Change = ((Mean stability samples − Mean comparison samples)/Mean comparison samples) × 100
LQC: low-quality control; HQC: high-quality control; CV: coefficient of variation.
aMean of six replicates at each level.

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