International Scholarly Research Notices

Research Article

Effect of Antioxidant Treatment on Fibrogenesis in Rats with Carbon Tetrachloride-Induced Cirrhosis

Table 2

Effects of quercetin (Q) on lipid peroxidation and on antioxidant enzyme activities in CCl4-induced hepatic injury.
ParametersExperimental groups
COCCl4CCl4 + Q
TBARS (nmol/mg protein) 0 . 1 9 ± 0 . 0 0 1 0 . 3 7 ± 0 . 0 2 a 0 . 2 8 ± 0 . 0 2 b
SOD (U SOD/mg protein) 3 . 8 6 ± 0 . 2 8 1 . 4 1 ± 0 . 2 2 a 3 . 3 6 ± 0 . 2 9
CAT (p mol/mg protein) 0 . 6 2 ± 0 . 0 4 0 . 2 7 ± 0 . 0 2 a 0 . 5 5 ± 0 . 0 2
GPx (mmol/min/mg protein) 0 . 2 7 ± 0 . 0 2 0 . 1 9 ± 0 . 0 1 a 0 . 2 3 ± 0 . 0 1
GSH (mmol/mg protein) 3 6 2 . 1 ± 4 6 . 6 3 2 3 0 . 6 6 ± 3 5 . 0 9 a 3 7 1 . 6 ± 3 3 . 8
GSSG (nmol/mg protein) 4 0 . 6 3 ± 1 . 8 7 8 4 . 4 6 ± 3 . 4 5 a 4 9 . 9 6 ± 3 . 7 4
GSH/GSSG (Ratio) 8 . 9 1 ± 1 . 0 6 2 . 7 4 ± 0 . 4 2 a 7 . 4 3 ± 0 . 8 0
Results represent mean ± S.E.
aSignificant difference between CCl4 group and groups CO, CCl4 + Q, considering 𝑃 < 0 . 0 5 .
bSignificant difference between CCl4 + Q group and groups CO, considering 𝑃 < 0 . 0 5 .