Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 763127, 9 pages
http://dx.doi.org/10.5402/2012/763127
Research Article

In Vitro and In Vivo Evaluation of pH-Sensitive Hydrogels of Carboxymethyl Chitosan for Intestinal Delivery of Theophylline

Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Karnataka, Mysore 570 015, India

Received 19 March 2012; Accepted 29 April 2012

Academic Editors: R. Cao, R. Gozalbes, and P.-W. Hsieh

Copyright © 2012 Hemant Kumar Singh Yadav and H. G. Shivakumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Kumar and N. V. Majeti, “A review of chitin and chitosan applications,” Reactive and Functional Polymers, vol. 46, no. 1, pp. 1–27, 2000. View at Google Scholar · View at Scopus
  2. M. Amiji and R. Hejazi, “Chitosan-based gastrointestinal delivery systems,” Journal of Controlled Release, vol. 89, no. 2, pp. 151–165, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. S. Hoffman, “Hydrogels for biomedical applications,” Advanced Drug Delivery Reviews, vol. 54, no. 1, pp. 3–12, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Guo, J. Yuan, L. Yao, and Q. Gao, “Preparation and release profiles of pH/temperature-responsive carboxymethyl chitosan/P(2-(dimethylamino) ethyl methacrylate) semi-IPN amphoteric hydrogel,” Colloid and Polymer Science, vol. 285, no. 6, pp. 665–671, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. X. G. Chen, Z. Wang, W. S. Liu, and H. J. Park, “The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts,” Biomaterials, vol. 23, no. 23, pp. 4609–4614, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. E. Mathew, J. C. Mohan, K. Manzoor, S. V. Nair, H. Tamura, and R. Jayakumar, “Folate conjugated carboxymethyl chitosan-manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells,” Carbohydrate Polymers, vol. 80, no. 2, pp. 442–448, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Dev, J. C. Mohan, V. Sreeja et al., “Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications,” Carbohydrate Polymers, vol. 79, no. 4, pp. 1073–1079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Wang, B. Liu, J. Ren et al., “Preparation and characterization of new quaternized carboxymethyl chitosan/rectorite nanocomposite,” Composites Science and Technology, vol. 70, no. 7, pp. 1161–1167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. I. M. El-Sherbiny, “Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: preparation and in-vitro assessment,” Carbohydrate Polymers, vol. 80, no. 4, pp. 1125–1136, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. S. H. Park, M. K. Chun, and H. K. Choi, “Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex,” International Journal of Pharmaceutics, vol. 347, no. 1-2, pp. 39–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. G. B. Joshi, H. Ksy, M. N. Singh, and H. G. Shivakumar, “Development of pH sensitive hydrogel for intestinal delivery of methyl prednisolone using novel chitosan derivative,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, no. 1, pp. 200–203, 2011. View at Google Scholar · View at Scopus
  12. X. G. Chen and H. J. Park, “Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions,” Carbohydrate Polymers, vol. 53, no. 4, pp. 355–359, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. H. Lin, H. F. Liang, C. K. Chung, M. C. Chen, and H. W. Sung, “Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs,” Biomaterials, vol. 26, no. 14, pp. 2105–2113, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. J. Dong and M. H. Feng, “Synthesis and properties of O-carboxymethyl chitosan/methoxypoly(ethylene glycol) graft copolymers,” Journal of Materials Science, vol. 19, pp. 869–876, 2008. View at Google Scholar
  15. L. Chen, Z. Tian, and Y. Du, “Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices,” Biomaterials, vol. 25, no. 17, pp. 3725–3732, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. K. P. R. Chowdary and Y. Srinivasa Rao, “Preparation and evaluation of mucoadhesive microcapsules of indomethacin,” Indian Journal of Pharmaceutical Sciences, vol. 65, no. 1, pp. 49–52, 2003. View at Google Scholar · View at Scopus
  17. Z. Muskó, K. Pintye-Hódi, R. Gáspár et al., “Study of in vitro and in vivo dissolution of theophylline from film-coated pellets,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 51, no. 2, pp. 143–146, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Om, R. Rajat, and P. D. Sethi, Quantitative Analysis of Drugs in Pharmaceutical Formulation, CBS Publishers & Distributors, New Delhi, India, 3rd edition, 2008.
  19. S. Abreu, F. Campana, and R. Fernanda, “Preparation and characterization of carboxymethyl chitosan. Polímeros,” Ciência e Tecnologia, vol. 15, pp. 79–83, 2005. View at Google Scholar