Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 764510, 5 pages
http://dx.doi.org/10.5402/2012/764510
Research Article

Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis

1Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
2Morishita Jintan Co. Osaka Technocenter, 2-11-1, Tudayamate, Hirakata, Osaka 573-0128, Japan

Received 13 December 2011; Accepted 10 January 2012

Academic Editor: G. Ragno

Copyright © 2012 Yoshifumi Murata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.