Carbonic Anhydrase I as a New Plasma Biomarker for Prostate Cancer

Table 2

Summary of protein identification by tandem mass spectrometry.

ID	𝑚/𝑧	RT* (min)	Charge	Normal; (mean ± SD)	PCa*	𝑃 Values**	Mascot; score	Peptide sequence	Protein description	Uniprot ID
					(mean ± SD)
396	643.7	41.6	3	27.35 ± 13.42	63.53 ± 67.39	0.015	95.02	HDTSLKPISVSYNPATAK	Carbonic anhydrase 1	CAH1_HUMAN
310	790.9	47.8	2	24.96 ± 9.73	62.84 ± 72.61	0.016	72.71	ESISVSSEQLAQFR	Carbonic anhydrase 1	CAH1_HUMAN
983	753.0	47.5	3	16.02 ± 4.60	30.40 ± 27.50	0.017	71.62	EIINVGHSFHVNFEDNDNR	Carbonic anhydrase 1	CAH1_HUMAN
1463	719.4	51.8	2	25.20 ± 22.26	11.26 ± 2.32	0.030	66.87	GLEEELQFSLGSK	Complement C4-A	CO4A_HUMAN
1656	872.4	46.0	2	16.99 ± 5.22	25.86 ± 19.63	0.041	66.24	LYPIANGNNQSPVDIK	Carbonic anhydrase 1	CAH1_HUMAN
311	513.8	37.2	2	37.71 ± 16.18	86.33 ± 85.17	0.010	59.09	YSSLAEAASK	Carbonic anhydrase 1	CAH1_HUMAN
798	585.3	45.4	2	21.08 ± 6.68	43.99 ± 34.82	0.004	56.32	SADFTNFDPR	Carbonic anhydrase 2	CAH2_HUMAN
278	485.8	47.6	2	40.70 ± 20.28	91.91 ± 92.78	0.013	50.23	VLDALQAIK	Carbonic anhydrase 1	CAH1_HUMAN
538	493.2	41.0	2	20.19 ± 5.79	47.30 ± 52.18	0.016	44.71	GGPFSDSYR	Carbonic anhydrase 1	CAH1_HUMAN
2429	680.4	47.5	2	27.43 ± 10.68	20.70 ± 3.90	0.032	43.87	LNDLEDALQQAK	Keratin, type II cytoskeletal 1	K2C1_HUMAN
1369	714.4	48.1	3	21.16 ± 5.02	31.96 ± 19.53	0.014	43.57	YDPSLKPLSVSYDQATSLR	Carbonic anhydrase 2	CAH2_HUMAN
916	494.3	48.9	2	12.19 ± 4.64	31.68 ± 32.02	0.006	39.1	VVDVLDSIK	Carbonic anhydrase 2	CAH2_HUMAN
747	920.8	45.3	3	14.00 ± 4.82	35.85 ± 40.39	0.013	36.65	SLLSNVEGDNAVPMQHNNRPTQPLK	Carbonic anhydrase 1	CAH1_HUMAN
1596	656.3	36.6	2	9.93 ± 2.84	19.94 ± 16.30	0.006	33.83	QSPVDIDTHTAK	Carbonic anhydrase 2	CAH2_HUMAN
3781	826.1	40.2	3	4.72 ± 0.94	9.10 ± 9.25	0.027	32.29	TSETKHDTSLKPISVSYNPATAK	Carbonic anhydrase 1	CAH1_HUMAN
1199	538.3	40.7	3	19.72 ± 3.65	30.15 ± 23.16	0.036	30.33	YSAELHVAHWNSAK	Carbonic anhydrase 1	CAH1_HUMAN

∗Abbreviation: RT: retention time; PCa: prostate cancer
∗∗Welch's t-test.