Research Article

[Retracted] Interaction of TMPyP4, TMPyP3, and TMPyP2 with Intramolecular G-Quadruplex Formed by Promoter Region of Bcl2 and KRAS NHPPE

Table 4

Fluorescence spectroscopic data obtained for TMPyP4, TMPyP3, and TMPyP2 with Bcl2 and KRAS NHPPE-G-quadruplex DNA.

S. no.Name of G-quadrupelx DNA and porphyrin% Fluorescence hypochromicityConcentration of G-quadruplex DNA

139Bcl2-TMPyP428.78%306 nM
239Bcl2-TMPyP353.07%306 nM
339Bcl2-TMPyP212.56%306 nM
4KRAS NHPPE-TMPyP417.05%218 nM
5KRAS NHPPE-TMPyP321.05%218 nM
6KRAS NHPPE-TMPyP214.18%218 nM

% Fluorescence hypochromicity ( % F H ) = [ ( 𝐹 𝑝 𝐹 𝑏 𝑝 ) / 𝐹 𝑝 ] × 1 0 0 , where 𝐹 𝑝 is the fluorescence intensity of free porphyrin and 𝐹 𝑏 𝑝 is the fluorescence intensity of bound porphyrin.