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Research Article

Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

Table 1

Hematological values of female rats in chronic toxicity of ZA extract.
ControlZA extract
1 g/kg2 g/kg4 g/kg8 g/kga8 g/kgb
RBC (×106/μl) 7 . 5 7 ± 0 . 1 1 7 . 6 1 ± 0 . 1 7 7 . 1 3 ± 0 . 2 4 7 . 2 6 ± 0 . 0 9 7 . 0 5 ± 0 . 3 0 7 . 3 2 ± 0 . 1 1
HGB (g/dL) 1 5 . 2 0 ± 0 . 1 8 1 4 . 9 4 ± 0 . 8 4 1 4 . 3 6 ± 0 . 4 3 1 4 . 4 8 ± 0 . 2 0 1 4 . 7 8 ± 0 . 1 4 1 5 . 0 7 ± 0 . 2 1
HCT (%) 4 6 . 1 0 ± 0 . 5 8 4 6 . 9 0 ± 1 . 0 4 4 3 . 4 0 ± 1 . 5 4 4 4 . 2 0 ± 0 . 6 1 4 2 . 8 0 ± 1 . 8 1 * 4 6 . 0 0 ± 0 . 6 0
MCV (fl) 6 0 . 6 0 ± 0 . 3 0 6 1 . 7 6 ± 0 . 4 9 * 6 0 . 7 7 ± 0 . 3 3 6 1 . 0 4 ± 0 . 3 4 6 0 . 8 5 ± 0 . 3 5 6 2 . 6 9 ± 0 . 2 0 *
MCH (pg) 2 0 . 0 8 ± 0 . 1 8 1 9 . 5 8 ± 0 . 9 6 2 0 . 1 3 ± 0 . 1 2 1 9 . 9 6 ± 0 . 1 1 2 1 . 4 8 ± 1 . 3 6 2 0 . 6 0 ± 0 . 0 6
MCHC (g/dL) 3 3 . 1 4 ± 0 . 2 5 3 1 . 6 7 ± 1 . 4 4 3 3 . 1 3 ± 0 . 3 2 3 2 . 6 9 ± 0 . 2 6 3 5 . 3 0 ± 2 . 2 5 3 2 . 8 3 ± 0 . 1 2
Platelet (×105/μl) 6 . 2 8 ± 0 . 3 8 6 . 1 4 ± 0 . 6 4 6 . 9 0 ± 0 . 6 6 6 . 9 6 ± 0 . 5 2 5 . 9 6 ± 0 . 6 2 6 . 9 4 ± 0 . 4 6
Values are expressed as mean ± SEM, 𝑛 = 1 0 .
*Significantly different from control, 𝑃 < 0 . 0 5 .
aA group was given ZA extract at 8 g/kg daily over 180 days.
bA satellite group was given ZA extract at 8 g/kg daily over 180 days followed by no treatment for 28 days.