|
| Pt | Age (years) | Gender | Height
(cm) | Weight (kg) | Diagnosis | Chemotherapy protocol and additional medications | Medications received 24 hr prior to observation | Medications received during preondansetron observation period | Medications received during postondansetron observation period |
|
| 1 | 11.5 | F | 146 | 34.5 | Before B-cell ALL | AALL 0232
Cyclophosphamide 1000 mg/m2 × 1
Cytarabine 75 mg/m2/d × 13
6-Mercaptopurine 60 mg/m2/d × 13
Vincristine 1.5 mg/m2 × 1
PEG Asparaginase 6000 IU/m2 × 1
IT Methotrexate 15 mg/m2 × 6
IT Cytarabine 70 mg/m2
Prednisone 60 mg/m2/d × 28 days
Daunorubicin 25 mg/m2/d × 4
Other:
Trimethoprim/sulfamethoxazole 160 mg (TMP) po BID × 3 days
Colace 100 mg po BID
Senokot 1 tablet po QHS | None | None | None |
|
| 2 | 16.5 | M | 181 | 68.6 | Osteogenic sarcoma | COG AOST 0331 Cycle 2, week 9
Methotrexate 12 g/m2
Other:
Trimethoprim/sulfamethoxazole 160 mg (TMP) q AM and 80 mg (TMP) po qPM × 3 days
Colace 100 mg po BID | None | None | Decadron 10 mg po × 1, 5 mg po × 1, Methotrexate 20 g IV × 1 |
|
| 3 | 16.8 | M | 167 | 52.2 | Extragonadal pure seminoma, stage 3 | CCG-8891/COG 9048
Cisplatin 20 mg/m2 × 5 days
Etoposide 100 mg/m2 × 5 d
Bleomycin 15 U/m2 × 1
Other:
Trimethoprim/sulfamethoxazole 160 mg (TMP) q AM and 80 mg (TMP) po qPM × 3 days
Colace 100 mg po BID
Senna2 tablets po BID
Lactulose 30 mL BID PRN
Codeine 16 mg q4h PRN | None | None | Ondansetron 8 mg po × 4
Decadron 10 mg × 2, 5 mg × 3
Nabilone 1 mg × 3
Colace 100 mg po × 1
Bleomycin 24 mg IV × 1
Etoposide 160 IV × 2, Cisplatin 32 mg × 2 |
|
| 4 | 16.5 | F | 164 | 53.2 | Nodular sclerosing Hodgkin’s
lymphoma, stage 1A | COG AOHD 0431 Cycle 2
Doxorubicin 25 mg/m2/day 1, 2
Vincristine 1.4 mg/m2 day 1, 8
Prednisone 40 mg/m2 day 1–7
Cyclophosphamide 600 mg/m2 day 1–7
G-CSF 5 mcg/kg d
Other:
Trimethoprim/sulfamethoxazole 160 mg (TMP) po BID × 3 days | Cascara 5 mL po × 1
Magnesium hydroxide 25 mL po × 1 | None | Ondansetron 8 mg × 3
Ranitidine 150 mg po × 1
Prednisone 30 mg × 1 Dimenhydrinate 50 mg
po × 1 |
|
| 5 | 16.6 | F | 177 | 55.6 | Nodular sclerosing Hodgkin’s
lymphoma, stage 3 | AHOD-0031 Cycle 2 with DECA
Doxorubicin 25 mg/m2/d × 2
Bleomycin 5 U/m2/d day 1, 10 U/m2/d day 8
Vincristine 1.4 mg/m2/d day 1, 8
Etoposide 100 mg/m2/d
Prednisone 40 mg/m2/d
Cyclophosphamide 800 mg/m2 × 1
Dexamethasone 10 mg/m2 day 1, 2
Cytarabine 3000 mg/m2 day 1, 2
Cisplatin 90 mg/m2 IV day 1
GCSF 5 mcg/kg/d
Other:
Trimethoprim/Sulfamethoxazole 160 mg (TMP) po BID × 3 days | Prednisone 35 mg po × 1 | None | Ondansetron 8 mg × 1
Dimenhydrinate 50 mg
IV × 2
Doxorubicin 42.5 mg
Bleomycin 8.5 U at Vincristine 2.4 mg at Etoposide 213 mg
Cyclophosphamide 1360 mg |
|
| 6 | 7.5 | M | 118 | 23.0 | Medulloblastoma | COG CNS 0331 Regimen B
Vincristine 1.5 mg/m2 day 1, 8
Cyclophosphamide 1000 mg/m2 day 1, 2
MESNA 360 mg/m2 × 3 doses with each Cyclophosphamide
Other:
Trimethoprim/sulfamethoxazole 80 mg (TMP) po BID × 3 days | None | None | Decadron 4 mg IV × 1, Ondansetron 4 mg IV × 1
Vincristine 1.4 mg IV
Mesna 325 mg IV, Cyclophosphamide 900 mg IV |
|
| 7 | 12.5 | M | 156 | 61.7 | Before B-cell ALL | AALL 0232
Cyclophosphamide 1000 mg/m2 × 1
Cytarabine 75 mg/m2/d × 13
6-Mercaptopurine 60 mg/m2/d × 13
Vincristine 1.5 mg/m2 × 1
PEG Asparaginase 6000 IU/m2 × 1
IT Methotrexate 15 mg/m2 × 6
IT Cytarabine 70 mg/m2
Prednisone 60 mg/m2/d × 28 days
Daunorubicin 25 mg/m2/d × 4
Other:
Trimethoprim/sulfamethoxazole 160 mg (TMP) po BID × 3 days
Domperidone 10 mg po QID
Citalopram 10 mg po daily
Omeprazole 20 mg po daily | Dimenhydrinate 50 mg
IV × 1 | None | Cyclophosphamide 800 mg IV × 1
Domperidone 10 mg × 1
6-Mercaptopurine
40 mg × 1 |
|
| 8 | 6.0 | M | 112 | 19.8 | Biphenotypic leukemia | Institutional Protocol
Ifosfamide 2.5 g/m2/d × 3
Etoposide 100 mg /m2/d × 3
Carboplatin 635 mg/m2 day 3
GCSF 5 mcg/kg/d
Other:
Trimethoprim/sulfamethoxazole 80 mg (TMP) po BID × 3 days
Dimenhydrinate 25 mg po q6h
PRN | Decadron 4 mg IV × 1
Voriconazole 100 mg po bid | None | Ondansetron 4 mg × 1
Decadron 2 mg IV × 1 |
|
| 9 | 14.8 | M | 171 | 88.2 | Before B-cell ALL | COG AALL 0232
Cyclophosphamide 1000 mg/m2 × 1
Cytarabine 75 mg/m2/d × 13
6-Mercaptopurine 60 mg/m2/d × 13
Vincristine 1.5 mg/m2 × 1
PEG Asparaginase 6000 IU/m2 × 1
IT Methotrexate 15 mg/m2 × 6
IT Cytarabine 70 mg/m2
Prednisone 60 mg/m2/d × 28 days
Daunorubicin 25 mg/m2/d × 4
Other:
Trimethoprim/Sulfamethoxazole 160 mg (TMP) po BID × 3 days | None | None | Cytarabine 150 mg IV
Cyclophosphamide 2 g IV
Ondansetron 8 mg IV × 1 |
|
| 10 | 13 | F | 139 | 33.5 | Before B-cell ALL relapse | Institutional Protocol Relapse 001 Maintenance
Cytarabine 2.9 mg/m2/d
Etoposide 290 mg/m2/d
Vincristine 0.7 mg/m2/d
Dexamethasone 6 mg/m2/d
Methotrexate po 200 mg/m2/d
6-Mercaptopurine 75 mg/m2/d
Cyclophosphamide 1100 mg/m2/d
× 1
Methotrexate IV 1000 mg/m2/d × 1
Leucovorin 10 mg/m2/d
IT Methotrexate 65 mg/m2/d
IT Cytarabine 25 mg/m2/d
Other:
Trimethoprim/Sulfamethoxazole 80 mg (TMP) po BID × 3 days
| None | None | Methotrexate
1100 mg IV × 1 |
|
| 11 | 10.8 | F | 154 | 43.8 | Osteogenic sarcoma | AOST 0331, Cycle 2 week 9
Methotrexate 12 g/m2
Other:
Trimethoprim/Sulfamethoxazole 160 mg (TMP) po BID × 3 days
Colace 100 mg po daily PRN
| Nabilone 0.3 mg po bid | None | Ondansetron 8 mg IV × 3, Decadron 8 mg IV/po prechemo,
Decadron 4 mg IV/po
q6h × 3,
Nabilone 0.5 mg po BID,
Diphenhydramine
50 mg IV |
|
| 12 | 16.8 | M | 173 | 57.5 | Ewing’s sarcoma, stage 4 | AEWS0031 week 1
Vincristine 1.5 g/m2 day 1
Ifosfamide 3 g/m2 day 1, 2, 3
Doxorubicin 20 mg/m2 day 1, 2, 3
Etoposide 150 mg/m2 day 1, 2, 3
Other:
Trimethoprim/Sulfamethoxazole 160 mg (TMP) po BID × 3 days | Dimenhydrinate 25 mg
po × 1 | None | Ondansetron 8 mg × 2 Lactulose 10 mL po × 2
Decadron 10 mg IV × 1
Decadron 5 mg IV × 3 Furosemide 10 mg IV × 2, Nabilone 0.5–1 mg po × 2
Tylenol 975 mg po × 1
Dimenhydrinate 25 iv
q4h × 4 |
|
