Design and Development of Degradable Polyethylenimines for Delivery of DNA and Small Interfering RNA: An Updated Review

Figure 10

Tissue distribution of PEA/DNA (gWIZ-Luc) complexes administered by intravenous injection and inhalation at various N/P ratios. (*𝑃<0.1; **𝑃<0.05; ***𝑃<0.01, Student’s 𝑡-test, two-tailed): (a) intravenous injection (𝑛=4, error bars represent standard deviation) and (b) aerosol administration (𝑛=4, error bars represent standard deviation). Note that there was two mice dead among four mice due to the toxicity in the PEA/DNA complex at N/P 45 of intravenous injection; no toxicity was observed in all the other groups [53].

(a)

(b)