Table of Contents
ISRN Polymer Science
Volume 2012, Article ID 801827, 7 pages
http://dx.doi.org/10.5402/2012/801827
Research Article

Ethyl Cellulose Microparticles Containing Metformin HCl by Emulsification-Solvent Evaporation Technique: Effect of Formulation Variables

1Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, India
2Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, India

Received 7 January 2012; Accepted 29 January 2012

Academic Editors: I. Cheong and F. Fraga López

Copyright © 2012 Ruma Maji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The work investigates the effect of various formulation variables like drug-polymer ratio, stirring speed, and surfactant (Span 80) concentration on the properties of ethyl cellulose microparticles containing metformin HCl, prepared by emulsification solvent evaporation technique. The drug entrapment efficiency, particle size, and drug release behaviour of these microparticles were influenced by these formulation variables. The sustained release characteristic of these microparticles was more prominent in pH 6.8 than pH 1.2. The drug release from ethyl cellulose microparticles was found to follow the Fickian (diffusion-controlled) release mechanism. The drug-polymer interaction and surface topography of these microparticles were analyzed by FTIR spectroscopy and SEM, respectively.