Table of Contents
ISRN Organic Chemistry
Volume 2012, Article ID 810938, 9 pages
Research Article

Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides

1Chemistry of Heterocycles Group, Laboratory of Applied Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Annaba, P.O. Box 12, Annaba 23000, Algeria
2Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium

Received 11 January 2012; Accepted 2 February 2012

Academic Editors: G. Li, R. Luisi, and A. Schlapbach

Copyright © 2012 Mohamed Dehamchia and Zine Regainia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herein, we describe an efficient one-step synthesis of new fused benzothiadiazepine-1,1-dioxides and macrocyclic sulfamides. The synthesis of these compounds was achieved in moderate yields starting from previously described N,N′-disubstituted symmetric sulfamides and N-tert-butoxycarbonyl, N′-alkyl sulfamide. The chemical structures of all the new compounds reported in this work were confirmed by NMR, IR, and mass spectrometry. These compounds are beneficial building blocks that can be used in deriving new chemical entities that exert a wide spectrum of pharmacological activities.