International Scholarly Research Notices / 2012 / Article / Tab 3

Research Article

Normal and Reversed-Phase HPTLC Methods for Simultaneous Estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical Formulation

Table 3

Validation parameters.

MethodMethod IMethod II
ParametersTELMIMETTELMIMET

Linearity (correlation coefficient)0.9970.9970.9960.998
Slope3.4430.3810.8270.660
Intercept2589732.1803.51135
Ruggedness (% RSD)
 Analyst-I ( 𝑛 = 6 )0.711.520.630.90
 Analyst-II ( 𝑛 = 6 )0.600.960.871.14
Robustness [% RSD] ( 𝑛 = 6 )
 Mobile phase composition0.410.690.870.29
 Duration of saturation time0.841.230.740.83
 Mobile phase volume1.491.050.430.43
 Development distance0.380.740.190.65
Sensitivity
 Limit of detection (ng)2.7958.6943.9764.18
 Limit of quantitation (ng)8.45177.86133.26194.49
Precision (% RSD)
 Intraday ( 𝑛 = 3 )0.44–0.730.62–0.970.51–0.670.51–1.13
 Interday ( 𝑛 = 3 )0.52–0.890.46–1.380.56–0.790.57–1.23
 Repeatability ( 𝑛 = 6 ) 0.75 1.401.020.86

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