Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals

Table 2

Comparison of assay results of proposed and reference methods.

Tablet brand name	Nominal amount, mg	Found (% of nominal amount ± SD)*
		Reference method	Proposed methods
			Method A	Method B
Practin^a	4	100.3±0.76	98.86±1.04	99.48±1.12
			𝑡=3.3	𝑡=2.9
			𝐹=4.5	𝐹=5.2
Ciplactin^b	4	100.8±0.85	98.76±1.87	99.26±2.00
			𝑡=3.6	𝑡=3.2
			𝐹=3.5	𝐹=4.3

*Mean value of five determinations.
**Marketed by: ^aWockhardt Ltd., India,^bCipla India Ltd., India.
Tabulated 𝑡value at the 95% confidence level is 2.78; tabulated 𝐹value at the 95% confidence level is 6.39.