Table of Contents
ISRN Anesthesiology
Volume 2012, Article ID 816984, 6 pages
http://dx.doi.org/10.5402/2012/816984
Clinical Study

Comparative Effects of Single Shot Intrathecal Bupivacaine with Dexmedetomidine and Bupivacaine with Fentanyl on Labor Outcome

1Obstetric Anesthesia Unit, Department of Anesthesia, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
2Department Obstetrics and Gynecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Received 21 October 2012; Accepted 26 November 2012

Academic Editors: A. Mizutani, S. Siddik-Sayyid, C. Tong, and A. Wiebalck

Copyright © 2012 S. Fyneface-Ogan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. E. Onah, S. N. Obi, T. C. Oguanuo, H. A. Ezike, C. M. Ogbuokiri, and J. O. Ezugworie, “Pain perception among parturients in Enugu, South-Eastern Nigeria,” Journal of Obstetrics and Gynaecology, vol. 27, no. 6, pp. 585–588, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Fyneface-Ogan, C. N. Mato, and S. E. Anya, “Epidural anesthesia: views and outcomes of women in labor in a Nigerian hospital,” Annals of African Medicine, vol. 8, no. 4, pp. 250–256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Reynolds and J. A. Crowhurst, “Opioids in labour—no analgesic effect,” The Lancet, vol. 349, no. 9044, pp. 4–5, 1997. View at Google Scholar · View at Scopus
  4. A. H. Lebovits, P. Zenetos, D. K. O'Neill et al., “Satisfaction with epidural and intravenous patient-controlled analgesia,” Pain Medicine, vol. 2, no. 4, pp. 280–286, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Adeyemi, R. Vernon, and O. Medge, “A spinal labour analgesia protocol for Ghana,” in Proceedings of the 4th All Africa Anaesthesia Congress, pp. 67–68, 2009.
  6. J. Bogra, N. Arora, and P. Srivastava, “Synergistic effect of intrathecal fentanyl and bupivacaine in spinal anesthesia for cesarean section,” BMC Anesthesiology, vol. 5, article 5, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Vyas, D. K. Sahu, and R. Parampill, “Comparative study of intrathecal sufentanil bupivacaine versus intrathecal bupivacaine in patients undergoing elective cesarean section,” Journal of Anaesthesiology Clinical Pharmacology, vol. 26, no. 4, pp. 488–492, 2010. View at Google Scholar
  8. A. Lehavi, P. Abecasis, A. Weissman, A. Winterstern, and Y. S. Katz, “Subarachnoid block with hyperbaric bupivacaine and morphine may shorten PACU stay after cesarean delivery,” Journal of Perianesthesia Nursing, vol. 25, no. 6, pp. 371–379, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Labbene, H. Gharsallah, A. Abderrahman et al., “Effects of 15 mcg intrathecal clonidine added to bupivacaine and sufentanil for labor analgesia,” La Tunisie Medicale, vol. 89, no. 11, pp. 853–859, 2011. View at Google Scholar
  10. R. Gupta, R. Verma, J. Bogra, M. Kohli, R. Raman, and J. K. Kushwaha, “A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine,” Journal of Anaesthesiology Clinical Pharmacology, vol. 27, no. 3, pp. 339–343, 2011. View at Google Scholar
  11. E. Martin, G. Ramsay, J. Mantz, and S. T. J. Sum-Ping, “The role of the α2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit,” Journal of Intensive Care Medicine, vol. 18, no. 1, pp. 29–41, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Kalso, R. Poyhia, and P. H. Rosenberg, “Spinal antinociception by dexmedetomidine, a highly selective α2-adrenergic agonist,” Pharmacology and Toxicology, vol. 68, no. 2, pp. 140–143, 1991. View at Google Scholar · View at Scopus
  13. P. R. Bromage, Epidural Analgesia, WB Saunders, Philadelphia, Pa, USA, 1978.
  14. C. A. Wong, B. M. Scavone, J. P. Slavenas et al., “Efficacy and side effect profile of varying doses of intrathecal fentanyl added to bupivacaine for labor analgesia,” International Journal of Obstetric Anesthesia, vol. 13, no. 1, pp. 19–24, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. B. S. Sethi, M. Samuel, and D. Sreevastava, “Efficacy of analgesic effects of low dose intrathecal clonidine as adjuvant to bupivacaine,” Indian Journal of Anaesthesia, vol. 51, pp. 415–419, 2007. View at Google Scholar
  16. M. D. Owen, O. Özsaraç, S. Şahin, N. Uçkunkaya, N. Kaplan, and I. Maǧunaci, “Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia,” Anesthesiology, vol. 92, no. 2, pp. 361–366, 2000. View at Google Scholar · View at Scopus
  17. Y. Harada, K. Nishioka, L. M. Kitahata, K. Kishikawa, and J. G. Collins, “Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H,” Anesthesiology, vol. 83, no. 2, pp. 344–352, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Bonnet, V. B. Buisson, Y. Francois, P. Catoire, and M. Saada, “Effects of oral and subarachnoid clonidine on spinal anesthesia with bupivacaine,” Regional Anesthesia, vol. 15, no. 4, pp. 211–214, 1990. View at Google Scholar · View at Scopus
  19. P. E. Gautier, M. de Kock, L. Fanard, A. van Steenberge, and J. L. Hody, “Intrathecal clonidine combined with sufentanil for labor analgesia,” Anesthesiology, vol. 88, no. 3, pp. 651–656, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. J. E. Mattingly, J. D'Alessio, and J. Ramanathan, “Effects of obstetric analgesics and anesthetics on the neonate: a review,” Pediatric Drugs, vol. 5, no. 9, pp. 615–627, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Gertler, H. C. Brown, D. H. Mitchell, and E. N. Silvius, “Dexmedetomidine: a novel sedative-analgesic agent,” Proceedings (Baylor University Medical Center), vol. 14, pp. 13–21, 2001. View at Google Scholar
  22. C. Olofsson, A. Ekblom, G. Ekman-Ordeberg, and L. Irestedt, “Obstetric outcome following epidural analgesia with bupivacaine-adrenaline 0.25% or bupivacaine 0.125% with sufentanilva prospective randomized controlled study in 1000 parturients,” Acta Anaesthesiologica Scandinavica, vol. 42, no. 3, pp. 284–292, 1998. View at Google Scholar · View at Scopus
  23. K. Fukushima, Y. Nishimi, K. Mori, and J. Takeda, “Effect of epidurally administered dexmedetomidine on sympathetic activity and postoperative pain in man,” Anesthesia and Analgesia, vol. 82, article S121, 1996. View at Google Scholar
  24. S. M. Al-Ghanem, I. M. Massad, M. M. Al-Mustafa et al., “Effect of adding dexmedetomidine versus fentanyl to intrathecal bupivacaine on spinal block characteristics in gynecological procedures: a double blind controlled study,” American Journal of Applied Sciences, vol. 6, no. 5, pp. 882–887, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. A. A. Weinbroum and R. Ben-Abraham, “Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain,” European Journal of Surgery, vol. 167, no. 8, pp. 563–569, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Klimscha, A. Chiari, P. Krafft et al., “Hemodynamic and analgesic effects of clonidine added repetitively to continuous epidural and spinal blocks,” Anesthesia and Analgesia, vol. 80, no. 2, pp. 322–327, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Strebel, J. A. Gurzeler, M. C. Schneider, A. Aeschbach, and C. H. Kindler, “Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study,” Anesthesia and Analgesia, vol. 99, no. 4, pp. 1231–1238, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. K. S. Filos, L. C. Goudas, O. Patroni, and V. Polyzou, “Hemodynamic and analgesic profile after intrathecal clonidine in humans: a dose-response study,” Anesthesiology, vol. 81, no. 3, pp. 591–601, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. C. O. Imarengiaye, “Trends in pain relief in labour: implications for obstetric analgesia service in Nigeria,” Nigerian Postgraduate Medical Journal, vol. 12, no. 3, pp. 193–202, 2005. View at Google Scholar