Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent

Table 4

Method robustness and ruggedness expressed as intermediate precision (% RSD).

(a) Titrimetry

	Robustness		Ruggedness
	Parameter altered
GNC taken, μg m^−1	Volume of H2SO4* (%RSD) (𝑛=3)	Reaction time* (%RSD) (𝑛=3)	Interanalysts, (%RSD) (𝑛=4)	Interburettes, (%RSD) (𝑛=4)
3.0	1.56	2.02	1.10	1.32
6.0	1.32	1.42	1.59	1.53
9.0	1.65	1.11	2.50	1.25

(b) Spectrophotometry

	Robustness		Ruggedness
	Parameter altered
GNC taken, μg m^−1	Volume of p-DMAB* (%RSD) (𝑛=3)	Reaction time* (%RSD) (𝑛=3)	Interanalysts, (%RSD) (𝑛=4)	Intercuvetts, (%RSD) (𝑛=4)
2.0	1.56	2.08	1.15	1.32
4.0	1.32	1.40	1.29	1.53
6.0	1.65	1.12	2.10	1.25

*Volumes of 5 M H₂SO₄ varied were 5±1 mL, and reaction times were 15±1 min.
*Volumes of p-DMAB varied were 1±0.1 mL, and reaction times were 15±1 min.