An Integrated Multiscale Mechanistic Model for Cancer Drug Therapy

Figure 5

(a) Cross-section of solid tumor embed in normal tissue. (b) Diffusion-convection drug transport model in solid tumor. (c) Drug transport mechanism in intratumoral space (to be continued). 𝐶_𝑖 and 𝐶_𝑣 are the drug concentrations in intratumoral fluid and tumor capillary respectively. Outward arrow indicates convection direction since intratumoral pressure is higher in the center than at the periphery of tumor (Figure 5(c)). (c) (Continued) Drug transport in intratumoral space.