Solubility Enhancement of Etoricoxib by Cosolvency Approach

Table 3

Solubility profile of etoricoxib in water-PG mixture at room temperature.

Water (% v/v)	PG (% v/v)	Dielectric constant	Solubility of etoricoxib (𝑆𝑚, mg/mL) (Mean ± S.D., 𝑛=3)
0	100	32.00	1.6657±0.0448
10	90	36.64	1.5431±0.0427
20	80	41.27	1.3487±0.0383
30	70	45.91	1.0899±0.0216
40	60	50.54	0.7581±0.0175
50	50	55.18	0.6122±0.0093
60	40	59.82	0.4486±0.0072
70	30	64.45	0.3187±0.0050
80	20	69.09	0.2250±0.0032
90	10	73.72	0.1479±0.0026
100	0	78.36	0.0767±0.0018