Solubility Enhancement of Etoricoxib by Cosolvency Approach

Table 4

Solubility profile of etoricoxib in water-glycerin mixture at room temperature.

Water (% v/v)	PG (% v/v)	Dielectric constant	Solubility of etoricoxib (𝑆𝑚, mg/mL) (Mean ± S.D., 𝑛=3)
0	100	42.50	0.8488±0.0196
10	90	46.09	0.8310±0.160
20	80	49.67	0.7099±0.0153
30	70	53.26	0.5893±0.0088
40	60	56.84	0.5314±0.0072
50	50	60.43	0.3400±0.0056
60	40	64.02	0.2961±0.0048
70	30	67.60	0.2291±0.0034
80	20	71.19	0.1978±0.0032
90	10	74.77	0.1309±0.0018
100	0	78.36	0.0767±0.0018