Table of Contents
ISRN Cardiology
Volume 2012, Article ID 824730, 6 pages
http://dx.doi.org/10.5402/2012/824730
Clinical Study

Is Leukocytosis a Predictor for Recurrence of Ischemic Events after Coronary Artery Bypass Graft Surgery? A Cohort Study

1Shahid Madani Heart Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland
3Azad University of Medical Sciences, Tabriz, Iran
4Northwest Health, NSW Australia, Tamworth, Australia
5Valiasr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Received 16 March 2012; Accepted 13 May 2012

Academic Editors: A. Becker and C. Hassager

Copyright © 2012 Farid Rashidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Studies have shown that inflammation plays an important role in pathogenesis of coronary artery disease. The present study was designed to evaluate the role of high WBC count before CABG in predicting the risk of ischemic events after CABG. Methods and Results. This prospective study was carried out on 380 patients who underwent CABG surgery. Ninety seven patients (25.5%) had recurrent ischemic event. Mean WBC count before CABG surgery in patients with recurrent ischemic event was 7267 mic/lit ± 1863, which was significantly higher than the others, with a mean WBC count of 6721 mic/lit ± 1734 ( 𝑃 = 0 . 0 1 1 ). Patients with a WBC count more than 6000 mic/lit were at the highest risk for recurrent ischemic event (OR = 2.11, 95% CI = 1.18–3.44, 𝑃 = 0 . 0 0 9 ). After adjustment for age, sex, family history, smoking, hyperlipidemia, Logestic Euro score, post opretive enzyme release (CK.mb), arterial graft and BMI, the relationship between the group with WBC count higher than 6000 mic/lit and recurrent of ischemic event remained significant (OR = 2.25, 95% CI = 1.2 to 4, 𝑃 = 0 . 0 0 5 ). Conclusions. High WBC count before CABG surgery is an independent risk factor for ischemic events one year after the surgery.