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ISRN Biochemistry
Volume 2012 (2012), Article ID 827604, 7 pages
Research Article

The Essence of ATP Coupling

Institute of Chemical Kinetics and Combustion, Novosibirsk State University, Institutskaya 3, Novosibirsk 630090, Russia

Received 13 December 2011; Accepted 29 January 2012

Academic Editor: L. Giuliani

Copyright © 2012 Nikolai Bazhin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The traditional explanation of ATP coupling is based on the raising of the equilibrium constants of the biochemical reactions. But in the frames of the detailed balance, no coupling occurs under thermodynamic equilibrium. The role of ATP in coupling is not that it provides an increase in the equilibrium constants of thermodynamically unfavorable reactions but that the unfavorable reactions are replaced by other reactions which kinetically are more favorable and give rise to the same products. The coupling with ATP hydrolysis results in the formation of quasistationary intermediate states.