Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling
Figure 3
Distribution of collagen fiber in lungs of the repeatedly antigen challenged mice. Lung tissue sections from mice at days 24 ((a) and (b)), 39 ((c) and (d)), and 54 ((e) and (f)) were studied by Masson’s trichrome staining (×40). Collagen fibers were found in the endothelium of vessel, the airway subepithelium and smooth muscle layer both in sensitized and challenged mice ((a) and (b)). Increased deposition of collagen in the airway subepithelium and smooth muscle layer was found in repeatedly challenged mice at day 54 (f), which was not observed in the airways of sensitized mice (e).
