Interplaying Factors That Effect Multiple Sclerosis Causation and Sustenance

Figure 11

A second set of potentially functional intracellular dimer sites on are displayed on MBP Isoform 1. The inclusive epitope pairs are: DNTFK, LQTIQ and DNTFK, QTIQE and NTFKD, LQTIQ and NTFKD, QTIQE with respective interval distances of 40 and 48 Ångströms. Dimeric IgE complexing hinges upon disruption of the overhanging oligodendrocyte membrane surface and facilitated intracellular autoantibody inflow. For serum antibody immunoassay purposes, the longer, inclusive peptide DNTFKD can be used together with LQTIQE as both peptides are sufficiently hydrophilic when coupled with the peptide-solubilizing, amino-ADOOA-ADOOA linker.