Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography
Table 2
SD-OCT RNFL thickness reproducibility.
Manual centration
Automatic centration
Mean RNFL in m (95% CI)
Sw
CV %
ICC (95% CI)
Mean RNFL in m (95% CI)
Sw
CV %
ICC (95% CI)
Average
98.35 (97.07–99.62)
1.6
0.65
0.999 (0.998–0.999)
98.57 (97.33–99.81)
1.3
0.63
0.983 (0.974–0.990)
Temporal
76.06 (74.59–77.53)
2.8
0.97
0.980 (0.970–0.988)
74.83 (73.54–76.11)
1.1
0.86
0.998 (0.998–0.999)
Superior
118.35 (116.36–120.31)
5.3
0.83
0.997 (0.995–0.998)
118.84 (116.95–120.73)
2.1
0.80
0.999 (0.983–0.999)
Nasal
71.80 (69.75–73.85)
3.2
1.43
0.989 (0.984–0.994)
72.86 (70.98–74.75)
2.4
1.29
0.998 (0.998–0.999)
Inferior
126.87 (124.83–128.91)
2.5
0.80
0.997 (0.995–0.998)
127.31 (125.35–129.27)
1.9
0.77
0.999 (0.999–0.999)
SD-OCT: spectral-domain optical coherence tomography; RNFL: retinal nerve fiber layer; CI: confidence intervals; Sw: within subject standard deviation; CV: coefficient of variation; ICC: intraclass correlation.
