Strain Echocardiography in Early Detection of Doxorubicin-Induced Left Ventricular Dysfunction in Children with Acute Lymphoblastic Leukemia

Table 1

The protocol of induction of remission in children with newly diagnosed acute lymphoblastic leukemia in the Hematology and Oncology Unit, the Pediatric Department, Faculty of Medicine, Tanta University.

Drug	Intake route	Dose	Instructions
Vincristine	IV	1.5 mg/m^2	Days 8, 15, 22, and 29
L-Asparaginase	IM	10000 IU/m^2	3 times a week for 9 doses
Prednisone	PO	60 mg/m^2/day	In TID: days 29–32
Prednisone	PO	30 mg/m^2/day	In TID: days 29–32
Prednisone	PO	15 mg/m^2/day	In TID: days 33–35, then discontinued on day 36
Triple therapy: Ara-C, methotrexate, and hydrocortisone	Intrathecal	Doses adjusted to the age	On days 1, 15, and 29
Conventional doxorubicin	IV	30 mg/m^2	Days 8, 15, 22, 29

IV: intravenously, IM: intramuscularly, PO: orally, TID: on three divided doses daily.